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Post Doctor

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Yunjie Xu

Research interest

Tumor-targeted therapy

Contact
office
Asan Sci. 337
E-mail
xuyunjie87 at 163.com
Publications
  • Park, M.; Sunwoo, K.; Kim, Y-J.; Won, M.; Xu, Y.; Kim, J.; Pu, Z.; Li, M.; Kim, J. Y.; Seo, J. H.; Kim, J. S. Cutting Off H+ Leaks on Inner Mitochondrial Membrane: A Proton Modulation Approach to Selectively Eradicate Cancer Stem Cells. J. Am. Chem. Soc. 2023, in press.
  • Xiong, H.; Xu, Y.; Kim, B.; Rha, H.; Zhang, B.; Li, M.; Yang, G-F.; Kim, J. S. Photo-Controllable Biochemistry: Exploiting Photocages in the Phototherapeutic Window. Chem 2023, 9, 29-64.
  • Li, M.; Xu, Y.; Peng, X.; Kim, J. S. From Low to No O2-Dependent Hypoxia Photodynamic Therapy (hPDT): A New Perspective. Acc. Chem. Res. 2022, 55, 3253-3264.
    • MORE VIEW
    • Xu, Y.; Xiong, H.; Zhang, B.; Lee, I.; Xie, J.; Li, M.; Zhang, H.; Kim, J. S., Photodynamic Alzheimer’s disease therapy: From molecular catalysis to photo-nanomedicine. Coordin. Chem. Rev. 2022, 470, 214726.
    • Li, C.; Guan, X.; Zhang, X.; Zhou, D.; Son, S.; Xu, Y.; Deng, M.; Guo, Z.; Sun, Y.; Kim, J. S., NIR-II bioimaging of small molecule fluorophores: From basic research to clinical applications. Biosensors and Bioelectronics., 2022, 216, 114620.
    • Li, M.; Xu, Y., Pu, Z., Xiong, T., Huang, H., Long, S., Son, S., Yu, L., Singh, N., Tong, Y., Sessler, J. L., Peng, X., Kim, J. S., Photoredox catalysis may be a general mechanism of photodynamic therapy. Proc. Natl. Acad. Sci. U.S.A. 2022, 119, e2210504119.
    • Yu, L.; Xu, Y.; Pu, Z.; Kang, H.; Li, M.; Sessler, J. L.; Kim, J. S., Photocatalytic Superoxide Radical Generator that Induces Pyroptosis in Cancer Cells. J. Am. Chem. Soc. 2022, 144, 11326-11337.
    • Y. Xu, Y. Wang, J. An, A. C. Sedgwick, M. Li, J. Xie, W. Hu, J. Kang, S. Sen, A. Steinbrueck, B. Zhang, L. Qiao, S. Wageh, J. F. Arambula, L. Liu, H. Zhang, J. L. Sessler, J. S. Kim, ‘2D-Ultrathin MXene/DOXjade Platform for Iron Chelation Chemo-photothermal Therapy’ Bioact. Mater. 76-85, 14, 2022.
    • J. Xie, Y. Wang, W. Choi, P. Jangili, Y. Ge, Y. Xu, J. Kang, L. Liu, B. Zhang, Z. Xie, J. He, N. Xie, G. Nie, H. Zhang, J. S. Kim, ‘Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies’ Chem. Soc. Rev. 9152-9201, 50, 2021.
    • Piao J, Liu S, Xu Y, et al. ‘Ezrin protein overexpression predicts the poor prognosis of pancreatic ductal adenocarcinomas’ Exp. Mol. Pathol., 98(1), 1-6, 2015.
    • Qu X, Sheng J, Shen L, Su J, Xu Y, Xie Q, Wu Y, Zhang X, Sun L. ‘Autophagy inhibitor chloroquine increases sensitivity to cisplatin in QBC939 cholangiocarcinoma cells by mitochondrial ROS’ Plos one, 16, 12(3), 2017.
    • Jin A, Xu Y, Liu S, Jin T, Li Z, Jin H, Lin L, Lin Z, ‘Sineoculis homeobox homolog 1 protein overexpression as an independent biomarker for pancreatic ductal adenocarcinoma’ Exp. Mol. Pathol., 96(1), 54-60, 2014.
    • Yunjie Xu, Weinan Gao, Yong Zhang et al, ‘ABT737 reverses cisplatin resistance via targeting glucose metabolism of human ovarian cancer cells’ Int. J. Oncol., 53(3), 1055-1068, 2018.

Snehasish Debnath

Research interest

Neuro-degenerative Disease, PDT, Drug delivery system, Bioimaging

Contact
office
Asan Sci. 548B
E-mail
snehasish14 at gmail.com
Publications
  • J. An, K. P. Lv, C. V. Chau, J. H. Lim, R. Parida, X. Huang, S. Debnath, Y. Xu, S. Zheng, A. C. Sedgwick, J. Y. Lee, D. Luo, Q. Liu, J. L. Sessler, and J. S. Kim, “Lutetium texaphyrin-celecoxib conjugate as a potential immuno-photodynamic therapy agent”, J. Am. Chem. Soc. 2024 (In Press).
  • Zhang, B. Guo, Y. Jiang, C. Hu, J. Kim, S. Debnath, X. Shi, C. Zhang, J. S. Kim, and F. Wang, “Luciferase-decorated gold nanorods as dual-modal contrast agents for tumor-targeted high-performance bioluminescence/photoacoustic imaging”, Anal. Chem. 2024, 96, 9132-9140.
    • MORE VIEW
    • R. Ghosh, R. R. Nair, S. Ghosh, S. Debnath, and P. B. Chatterjee, “A water-soluble wavy coordination polymer of Cu (II) as a turn-on luminescent probe for histidine and histidine-rich proteins/peptides”, Inorg. Chem. 2024, 63, 8320-8328.
    • S. Sen, A. Sinha, S. Banerjee, S. Debnath, A. Ghosh. J. Chakraborty and J. Gangopadhyay, “Noncovalent and covalent O-H~O interactions in PPh3O Cocrystals: A correlation study involving QTAIM, SAPT, NBO, and IBSI methods”, ACS Omega 2024, 9, 22476-22487.
    • R. Ghosh, S. Luhar, S. Debnath, K. B. Patel, K. Baskaran, D. N. Srivastava and P. B. Chatterjee, “Measurement of the malignancy marker spermine in human biofluids using smartphone readout and impedance techniques: Analytical validation using HPLC”, Sens. Actuat B. Chem. 2024, 406, 135390.
    • R. R. Nair, S. Debnath, R. Ghosh, A. Bhattacharya, M. Raju, and P. B. Chatterjee, “Label-free detection of unbound bilirubin and nitrophenol explosives in water by a mechanosynthesized dual functional zinc complex: Recognition of picric acid in various common organic media”, Chem. Eur. J., 2024, 30, e202303068.
    • S. Debnath, R. Ghosh, Pragti, S. Mukhopadhyay, K. Baskaran and P. B. Chatterjee, “Fabrication of paper-based facile and low-cost microfluidic device and digital imaging technique for point-of-need monitoring of hypochlorite”, Analyst, 2023, 148, 4072-4083.
    • S. Debnath, S. V. Navadiya, R. Ghosh, D. Pradhan and P. B. Chatterjee, “Coumarin-ensembled vanadium(V) compounds and their affinity studies toward biological thiols probed by fluorescence spectroscopy”, Chem. Asian J., 2023, 18, 202201162.
    • S. Debnath, R. Ghosh, R. R. Nair, D. Pradhan and P. B. Chatterjee, “Advances in the development of water-soluble fluorogenic probes for bioimaging of hypochlorite/hypochlorous acid in cells and organisms”, ACS Omega, 2022, 43, 38122-38149.
    • S. Debnath, R. R. Nair, R. Ghosh, K. Gaddam, N. Radhakishan, N. Nagesh and P. B. Chatterjee, “A unique water soluble probe for measuring the cardiac marker homocysteine and its clinical validation” Chem. Commun., 2022, 58, 9210-9213.
    • S. Debnath, and P. B. Chatterjee, “Enantiopure chiroptical probes for circular dichroism and absorbance based detection of nerve gas simulants” Chem. Commun., 2022, 58, 9006-9009.
    • S. Debnath, R. R. Nair, R. Ghosh, A. Bhattacharya, and P. B. Chatterjee, “Smartphone assisted chromogenic sensing of halogenated solvents and monoaromatic hydrocarbons” Dyes Pigm. 2021, 196, 109821.
    • S. N. Bhaduri, D. Ghosh, S. Debnath, R. Biswas, P. B. Chatterjee, and P. Biswas, “Copper(II)-incorporated porphyrin based porous organic polymer for a nonenzymatic electrochemical glucose sensor’, Inorg. Chem. 2023, 62, 4316-4146.
    • R. Ghosh, S. Debnath, A. Bhattacharya, and P. B. Chatterjee, “Affinity studies of hemicyanine derived water soluble colorimetric probes with reactive oxygen/nitrogen/sulfur species”, ChemBioChem. 2023, 24, 202200541.
    • A. Bhattacharya, R. Ghosh, S. Debnath and P. B. Chatterjee, “A simple, selective, and rapid detection-cum-precipitation of hazardous gold nanoparticles and their discrimination from gold(III) in environmental samples by a chromofluorogenic probe”, Sens. Actuat B. Chem. 2023, 378, 133158.
    • R. Ghosh, S. Debnath, A. Bhattacharya, D. Pradhan and P. B. Chatterjee, “Studies on the interaction between oxido/dioxidovanadium (V) compounds and reactive oxygen species: Synthesis, characterization, and photophysical investigation” J. Inorg. Biochem., 2022, 233, 111845.
    • R. R. Nair, M. Raju, S. Debnath, R. Ghosh and P. B. Chatterjee, “Concurrent detection and treatment of cyanide-contaminated water using mechanosynthesized receptors” Analyst. 2020, 145, 5647-5656.
    • R. R. Nair, S. Debnath, S. Das, P. Wakchaure, B. Ganguly and P. B. Chatterjee, “A highly selective turn-on biosensor for measuring spermine/spermidine in human urine and blood” ACS Appl. Bio Mater. 2019, 2, 2374-2387.
    • M. Raju, R. R. Nair, S. Debnath,and P. B. Chatterjee, “Affinity directed surface functionalization of two different metal nanoparticles by a natural ionophore: probing and removal of Hg2+ and Al3+ ions from aqueous solutions” Inorg. Chem. 2019, 58, 1674-1683.

안주성 (Jusung An)

Research interest

Fluorescence imaging and photodynamic therapy

Contact
office
Asan Sci. 346
E-mail
jusung0614 at korea.ac.kr
Publications
  • J. M. George, J. An, C. Yoon, D. Kim, S. Sharma, A. Sharma, J. S. Kim, ‘Fluorescence Imaging in Drug Delivery Systems’ Imaging Tools for Chemical Biology, 2024, in press.
  • F. Mehvari, V. Ramezanzade, J. An, J. Kim, M. Dinari, J. S. Kim‎, ‘Biopolymer-based hydrogels for biomedical applications: bioactivity and wound healing properties’ Coord. Chem. Rev., 2024, 518, 216093. Read here
  • J. An, K.-P. Lv, C. V. Chau, J. H. Lim, R. Parida, X. Huang, S. Debnath, Y. Xu, S. Zheng, A. C. Sedgwick, J. Y. Lee, D. Luo, Q. Liu, J. L. Sessler, J. S. Kim, ‘Lutetium Texaphyrin-Celecoxib Conjugate as a Potential Immuno-Photodynamic Therapy Agent’ J. Am. Chem. Soc., 2024, 146, 19434-19448. Read here
    • MORE VIEW
    • N. Singh, M. Won, J. An, C. Yoon, D. Kim, S. J. Lee, H. Kang, J. S. Kim, ‘Advances in covalent organic frameworks for cancer phototherapy’ Coord. Chem. Rev., 2024, 506, 215720. Read here
    • J. An, K. Kim, H. J. Lim, H. Y. Kim, J. Shin, I. Park, I. Cho, H. Y. Kim, S. Kim, C. McLean, K. Y. Choi, Y. Kim, K. H. Lee, J. S. Kim, ‘Early onset diagnosis in Alzheimer’s disease patients via amyloid-β oligomers-sensing probe in cerebrospinal fluid’ Nat. Commun., 2024, 15, 1004. Read here
    • S. Lee, J. Yoo, G. Bae, R. Thangam, J. Heo, J. Y. Park, H. Choi, C. Kim, J. An, J. Kim, K. R. Mun, S. Shin, K. Zhang, P. Zhao, Y. Kim, N. Kang, S.-B. Han, D. Kim, J. Yoon, M. Kang, J. Kim, L. Yang, S. Karamikamkar, J. Kim, Y. Zhu, A. H. Najafabadi, D.-H. Kim, K.-B. Lee, S. J. Oh, H.-C. Song, W. Y. Jang, L. Bian, Z. Chu, J. S. Kim, Y. S. Zhang, Y. Kim, H. S. Jang, S. Kim, H. Kang, ‘Photonic control of ligand nanospacing in self-assembly regulates stem cell fate’ Bioact. Mater., 2024, 34, 164-180. Read here
    • Y. Yang, M. Ma, L. Shen, J. An, E. Kim, H. Liu, M. Jin, S. Wang, J. Zhang, J. S. Kim, C. Yin, ‘A Fluorescent Probe for Investigating the Role of Biothiols in Signaling Pathways Associated with Cerebral Ischemia-Reperfusion Injury’ Angew. Chem., Int. Ed., 2023, 135, e202310408. Read here
    • H. -W. Kwon, J. An, J. S. Kim, I. -C. Kang, ‘Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells’ Biochem. Biophys. Rep., 2023, 35, 101517. Read here
    • M. A. Tekalgne, H. H. Do, T. V. Nguyen, Q. V. Le, J. An, S. H. Hong, S. H. Ahn, H. Kang, J. S. Kim, S. Y. Kim, ‘Efficient Electrocatalysts for Hydrogen Evolution Reaction using Heteroatom-Doped MXene Nanosheet’ Int. J. Energy Res., 2023, 2023, 8980888. Read here
    • J. Shin, J. An, J. Kim, Y. Noh, P. Jangili, J. S. Kim, ‘Ratiometric Fluorescent Chemosensors: Photophysical/Chemical Mechanism Principles and Design Strategies’ Fluorescent Chemosensors, 2023, 124-159.
    • Z. Zunbul, J. An, H. Aziz, J. Shin, S. Lim, Y. K. Kim, J. S. Kim, ‘Tailoring hydrophobicity of Thioflavin T to optimize Aβ fibril bioimaging’ Adv. Nanobiomed. Res., 2023, 3, 2200161. Read here
    • Z. Liu, Z. Han, X. Jin, J. An, J. Kim, W. Chen, J. S. Kim, J. Zheng, J. Deng, ‘Regulating the microenvironment with nanomaterials: Potential strategies to ameliorate COVID-19’ Acta Pharm. Sin. B, 2023 (in press). Read here
    • J. An, H. Hong, M. Won, H. Rha, Q. Ding, N. Kang, H. Kang, J. S. Kim, ‘Mechanical stimuli-driven cancer therapeutics’ Chem. Soc. Rev., 2023, 52, 30-46. Read here
    • Y. Xu, C. Li, J. An, X. Ma, J. Yang, L. Luo, Y. Deng, J. Kim, Y. Sun, ‘Construction of a 980 nm laser-activated Pt(II) metallacycle nanosystem for efficient and safe photo-induced bacteria sterilization’ Sci. China Chem., 2023, 66, 155-163. Read here
    • C. Zhang, J. An, J. Wu, W. Liu, H. Rha, J. S. Kim, P. Wang, ‘Structural modification of NIR-II fluorophores for angiography beyond 1300 nm: Expanding the xanthene universe’ Biosens. Bioelectron., 2022, 217, 114701. Read here
    • X. He, J.-T. Hou, X. Sun, P. Jangili, J. An, Y. Qian, J. S. Kim, J. Shen ‘NIR-II Photo-Amplified Sonodynamic Therapy Using Sodium Molybdenum Bronze Nanoplatform Against Subcutaneous Staphylococcus Aureus Infection’ Adv. Func. Mat., 2022, 38, 2203964. Read here
    • J. An, P. Verwilst, H. Aziz, J. Shin, S. Lim, I. Kim, Y. K. Kim, J. S. Kim, ‘Picomolar-Sensitive β-Amyloid Fibril Fluorophores by Tailoring the Hydrophobicity of Biannulated π-Elongated Dioxaborine-Dyes’ Bioact. Mater., 2022, 13, 239-248. Read here

    • Y. Xu, Y. Wang, J. An, A. C. Sedgwick, M. Li, J. Xie, W. Hu, J. Kang, S. Sen, A. Steinbrueck, B. Zhang, L. Qiao, S. Wageh, J. F. Arambula, L. Liu, H. Zhang, J. L. Sessler, J. S. Kim, ‘2D-Ultrathin MXene/DOXjade Platform for Iron Chelation Chemo-photothermal Therapy’ Bioact. Mater., 2022, 14, 76-85. Read here

    • Z. Mao, J. Xiong, P. Wang, J. An, F. Zhang, Z. Liu, J. S. Kim, ‘Activity-based Fluorescence Probes for Pathophysiological Peroxynitrite Fluxes’ Coord. Chem. Rev., 2022, 454, 214356. Read here

    • N. Singh, S. Son, J. An, I. Kim, M. Choi, N. Kong, W. Tao, J. S. Kim, ‘Nanoscale porous organic polymers for drug delivery and advanced cancer theranostics’ Chem. Soc. Rev., 2021, 50, 12883-12896. Read here

    • J. An, P. Jangili, S. Lim, Y. K. Kim, P. Verwilst, J. S. Kim ‘Multichromatic Fluorescence towards Aberrant Proteinaceous Aggregates utilizing Benzimidazole-based ICT Fluorophores’ J. Incl. Phenom. Macrocycl. Chem., 2021, 101, 205-215. Read here

    • S. Wang, W. X. Ren, J-T. Hou, M. Won, J. An, X. Chen, J. Shu and J. S. Kim ‘Fluorescence imaging of pathophysiological microenvironments’ Chem. Soc. Rev., 2021, 50, 8887-8902. Read here

    • E. Jung, I. Shim, J. An, M. S. Ji, P. Jangili, S-G. Chi, J. S. Kim ‘Phenylthiourea-conjugated BODIPY as an efficient photosensitizer for tyrosinase-positive melanoma-targeted photodynamic therapy’ ACS Appl. Bio Mater., 2021, 4, 2120-2127. Read here

    • Y. Ren, A. C. Sedgwick, J. Chen, G. Thiabaud, C. V. Chau, J. An, J. F. Arambula, X-P. He, J. S. Kim, J. L. Sessler, C. Liu ‘Manganese(II) Texaphyrin: A Paramagnetic Photoacoustic Contrast Agent Activated by Near-IR Light’ J. Am. Chem. Soc., 2020, 142, 16156-16160. Read here

    • J. Li, Y. Zhang, P. Wang, L. Yu, J. An, G. Deng, Y. Sun, J. S. Kim ‘Reactive Oxygen Species, Thiols and Enzymes Activable AIEgens from Single Fluorescence Imaging to Multifunctional Theranostics’ Coord. Chem. Rev., 2020, 427, 213559. Read here

    • Y. Xu, Y. Zhang, J. Li, J. An, C. Li, S. bai, A. Sharma, G. Deng, J. S. Kim, Y. Sun, ‘NIR-II Emissive Multifunctional AIEgen with Single Laser-Activated Synergistic Photodynamic/Photothermal Therapy of Cancers and Pathogens’ Biomaterials, 2020, 259, 120315. Read here

    • Y.-H. Zhang, X. Li, L. Huang, H. S. Kim, J. An, M. Lan, Q.-Y. Cao, J. S. Kim, ‘AIE based GSH activatable photosensitizer for imaging-guided photodynamic therapy’ Chem. Commun., 2020, 56, 10317-10320. Read here

    • Z. Xie, T. Fan, J. An, W. Choi, Y. Duo, Y. Ge, B. Zhang, G. Nie, N. Xie, H. Zhang, J. S. Kim, ‘Emerging combination strategies with phototherapy in cancer nanomedicine’ Chem. Soc. Rev., 2020, 49, 8065-8087. Read here

    • J. Wu, L. Jiang, P. Verwilst, J. An, H. Zeng, L. Zeng, G. Niu, J. S. Kim ‘A colorimetric and fluorescence lighting-up sensor based on ICT coupled with PET for rapid, specific and sensitive detection of nitrite in food’ Chem. Commun., 2019, 55, 9947-9950. Read here

Zhi Chen

Research interest

Light-controlled drug delivery, Optoelectronic biosensing

Contact
office
Asan Sci. 548B
E-mail
alexchen017010913@yahoo.com
Publications
  • Z. Chen, J. Li, T. Li, et al., ‘A CRISPR/Cas12a empowered Surface Plasmon Resonance Platform for Rapid and Specific Diagnosis of the Omicron Variant of SARS-CoV-2.’ Nat. Sci. Rev., 2022, 9, 8
  • Z. Chen, C. Meng, X. Wang, et al., ‘Ultrasensitive DNA Origami Plasmon Sensor for Accurate Detection in Circulating Tumor DNAs.’ Laser Photonics Rev., 2024, Read here
    • MORE VIEW
    • Z. Chen, C. Wu, Y. Yuan, et al., ‘CRISPR-Cas13a-powered electrochemical biosensor for the detection of the L452R mutation in clinical samples of SARS-CoV-2 variants.’ J. Nanobiotechnology, 2023, 21, 141.
    • Z. Chen, H. Huang, J. Deng, et al., ‘Light-guided Genetic Scissors Based on Phosphorene Quantum Dot.’ Laser Photonics Rev., 2024, Read here
    • J. Chen, Z. Chen, C. Meng, et al., ‘CRISPR-powered optothermal nanotweezers: Diverse bio-nanoparticle manipulation and single nucleotide identification.’ Light Sci. Appl., 2023, 12, 273.
    • F. Zheng, Z. Chen, J. Li, et al., ‘A Highly Sensitive CRISPR-Empowered Surface Plasmon Resonance Sensor for Diagnosis of Inherited Diseases with Femtomolar-Level Real-Time Quantification.’ Adv. Sci., 2022, 9, 14, e2105231
    • Y. Chen, Z. Chen, T. Li, et al., ‘Ultrasensitive and Specific Clustered Regularly Interspaced Short Palindromic Repeats Empowered a Plasmonic Fiber Tip System for Amplification-Free Monkeypox Virus Detection and Genotyping.’ ACS Nano, 2023, 17, 12903-12914
    • J. Shen, Z. Chen, R. Xie, et al., ‘CRISPR/Cas12a-Assisted Isothermal Amplification for Rapid and Specific Diagnosis of Respiratory Virus on an Microfluidic Platform.’ Biosens. Bioelectron., 2023, 237, 115523
    • C. Wu, Z. Chen, C. Li, et al., ‘CRISPR-Cas12a-Empowered Electrochemical Biosensor for Ultrasensitive Detection of SARS-CoV-2 Delta Variant.’ Nanomicro Lett., 2022, 14, 1, 159
    • X. Wang, X. Han, C. Li, Z. Chen, et al., ‘2D Materials for Bone Therapy.’ Adv. Drug Deliv. Rev., 2021, 178, 1, 113970


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