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Yunjie Xu (Research Professor)

Research interest

Tumor-targeted therapy

Contact
office
Asan Sci. 123A
E-mail
xuyunjie87 at 163.com
Publications
  • Park, M.; Sunwoo, K.; Kim, Y-J.; Won, M.; Xu, Y.; Kim, J.; Pu, Z.; Li, M.; Kim, J. Y.; Seo, J. H.; Kim, J. S. Cutting Off H+ Leaks on Inner Mitochondrial Membrane: A Proton Modulation Approach to Selectively Eradicate Cancer Stem Cells. J. Am. Chem. Soc. 2023, in press.
  • Xiong, H.; Xu, Y.; Kim, B.; Rha, H.; Zhang, B.; Li, M.; Yang, G-F.; Kim, J. S. Photo-Controllable Biochemistry: Exploiting Photocages in the Phototherapeutic Window. Chem 2023, 9, 29-64.
  • Li, M.; Xu, Y.; Peng, X.; Kim, J. S. From Low to No O2-Dependent Hypoxia Photodynamic Therapy (hPDT): A New Perspective. Acc. Chem. Res. 2022, 55, 3253-3264.
    • MORE VIEW
    • Xu, Y.; Xiong, H.; Zhang, B.; Lee, I.; Xie, J.; Li, M.; Zhang, H.; Kim, J. S., Photodynamic Alzheimer’s disease therapy: From molecular catalysis to photo-nanomedicine. Coordin. Chem. Rev. 2022, 470, 214726.
    • Li, C.; Guan, X.; Zhang, X.; Zhou, D.; Son, S.; Xu, Y.; Deng, M.; Guo, Z.; Sun, Y.; Kim, J. S., NIR-II bioimaging of small molecule fluorophores: From basic research to clinical applications. Biosensors and Bioelectronics., 2022, 216, 114620.
    • Li, M.; Xu, Y., Pu, Z., Xiong, T., Huang, H., Long, S., Son, S., Yu, L., Singh, N., Tong, Y., Sessler, J. L., Peng, X., Kim, J. S., Photoredox catalysis may be a general mechanism of photodynamic therapy. Proc. Natl. Acad. Sci. U.S.A. 2022, 119, e2210504119.
    • Yu, L.; Xu, Y.; Pu, Z.; Kang, H.; Li, M.; Sessler, J. L.; Kim, J. S., Photocatalytic Superoxide Radical Generator that Induces Pyroptosis in Cancer Cells. J. Am. Chem. Soc. 2022, 144, 11326-11337.
    • Y. Xu, Y. Wang, J. An, A. C. Sedgwick, M. Li, J. Xie, W. Hu, J. Kang, S. Sen, A. Steinbrueck, B. Zhang, L. Qiao, S. Wageh, J. F. Arambula, L. Liu, H. Zhang, J. L. Sessler, J. S. Kim, ‘2D-Ultrathin MXene/DOXjade Platform for Iron Chelation Chemo-photothermal Therapy’ Bioact. Mater. 76-85, 14, 2022.
    • J. Xie, Y. Wang, W. Choi, P. Jangili, Y. Ge, Y. Xu, J. Kang, L. Liu, B. Zhang, Z. Xie, J. He, N. Xie, G. Nie, H. Zhang, J. S. Kim, ‘Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies’ Chem. Soc. Rev. 9152-9201, 50, 2021.
    • Piao J, Liu S, Xu Y, et al. ‘Ezrin protein overexpression predicts the poor prognosis of pancreatic ductal adenocarcinomas’ Exp. Mol. Pathol., 98(1), 1-6, 2015.
    • Qu X, Sheng J, Shen L, Su J, Xu Y, Xie Q, Wu Y, Zhang X, Sun L. ‘Autophagy inhibitor chloroquine increases sensitivity to cisplatin in QBC939 cholangiocarcinoma cells by mitochondrial ROS’ Plos one, 16, 12(3), 2017.
    • Jin A, Xu Y, Liu S, Jin T, Li Z, Jin H, Lin L, Lin Z, ‘Sineoculis homeobox homolog 1 protein overexpression as an independent biomarker for pancreatic ductal adenocarcinoma’ Exp. Mol. Pathol., 96(1), 54-60, 2014.
    • Yunjie Xu, Weinan Gao, Yong Zhang et al, ‘ABT737 reverses cisplatin resistance via targeting glucose metabolism of human ovarian cancer cells’ Int. J. Oncol., 53(3), 1055-1068, 2018.

Snehasish Debnath (Research Professor)

Research interest

Neuro-degenerative Disease, PDT, Drug delivery system, Bioimaging

Contact
office
Asan Sci. 548B
E-mail
snehasish14 at gmail.com
Publications
  • C. Wang, F. Yuan, Z. Yan, T. Zhang, C. Fu, Y. Li, G. Dai, H. S. Kim, S. Xia, L. Yu, S. Debnath, W. X. Ren, J. Shu, M. Qiu, and J. S. Kim, “High entropy 2D layered double hydroxide nanosheet toward cascaded nanozyme-initiated chemodynamic and immune synergistic therapy”, J. Am. Chem. Soc. 2024 (in press).
  • J. An, K. P. Lv, C. V. Chau, J. H. Lim, R. Parida, X. Huang, S. Debnath, Y. Xu, S. Zheng, A. C. Sedgwick, J. Y. Lee, D. Luo, Q. Liu, J. L. Sessler, and J. S. Kim, “Lutetium texaphyrin-celecoxib conjugate as a potential immuno-photodynamic therapy agent”, J. Am. Chem. Soc. 2024, 146, 28, 19434-19448.
    • MORE VIEW
    • Zhang, B. Guo, Y. Jiang, C. Hu, J. Kim, S. Debnath, X. Shi, C. Zhang, J. S. Kim, and F. Wang, “Luciferase-decorated gold nanorods as dual-modal contrast agents for tumor-targeted high-performance bioluminescence/photoacoustic imaging”, Anal. Chem. 2024, 96, 9132-9140.
    • R. Ghosh, D. Pradhan, S. Debnath, A. Mansingh, N. Nagesh, and P. B. Chatterjee, “A hydrogen-bonded non-porous organic inorganic framework for measuring cysteine in blood plasma and endogenous cancer cell”, Chem. Eur. J. 2024, 30, e202401255.
    • R. Ghosh, R. R. Nair, S. Ghosh, S. Debnath, and P. B. Chatterjee, “A water-soluble wavy coordination polymer of Cu (II) as a turn-on luminescent probe for histidine and histidine-rich proteins/peptides”, Inorg. Chem. 2024, 63, 8320-8328.
    • R. Ghosh, S. Luhar, S. Debnath, K. B. Patel, K. Baskaran, D. N. Srivastava and P. B. Chatterjee, “Measurement of the malignancy marker spermine in human biofluids using smartphone readout and impedance techniques: Analytical validation using HPLC”, Sens. Actuat B. Chem. 2024, 406, 135390.
    • R. R. Nair, S. Debnath, R. Ghosh, A. Bhattacharya, M. Raju, and P. B. Chatterjee, “Label-free detection of unbound bilirubin and nitrophenol explosives in water by a mechanosynthesized dual functional zinc complex: Recognition of picric acid in various common organic media”, Chem. Eur. J., 2024, 30, e202303068.
    • S. Debnath, R. Ghosh, Pragti, S. Mukhopadhyay, K. Baskaran and P. B. Chatterjee, “Fabrication of paper-based facile and low-cost microfluidic device and digital imaging technique for point-of-need monitoring of hypochlorite”, Analyst, 2023, 148, 4072-4083.
    • S. Debnath, S. V. Navadiya, R. Ghosh, D. Pradhan and P. B. Chatterjee, “Coumarin-ensembled vanadium(V) compounds and their affinity studies toward biological thiols probed by fluorescence spectroscopy”, Chem. Asian J., 2023, 18, 202201162.
    • S. Debnath, R. Ghosh, R. R. Nair, D. Pradhan and P. B. Chatterjee, “Advances in the development of water-soluble fluorogenic probes for bioimaging of hypochlorite/hypochlorous acid in cells and organisms”, ACS Omega, 2022, 43, 38122-38149.
    • S. Debnath, R. R. Nair, R. Ghosh, K. Gaddam, N. Radhakishan, N. Nagesh and P. B. Chatterjee, “A unique water soluble probe for measuring the cardiac marker homocysteine and its clinical validation” Chem. Commun., 2022, 58, 9210-9213.
    • S. Debnath, and P. B. Chatterjee, “Enantiopure chiroptical probes for circular dichroism and absorbance based detection of nerve gas simulants” Chem. Commun., 2022, 58, 9006-9009.
    • S. Debnath, R. R. Nair, R. Ghosh, A. Bhattacharya, and P. B. Chatterjee, “Smartphone assisted chromogenic sensing of halogenated solvents and monoaromatic hydrocarbons” Dyes Pigm. 2021, 196, 109821.
    • S. N. Bhaduri, D. Ghosh, S. Debnath, R. Biswas, P. B. Chatterjee, and P. Biswas, “Copper(II)-incorporated porphyrin based porous organic polymer for a nonenzymatic electrochemical glucose sensor’, Inorg. Chem. 2023, 62, 4316-4146.
    • R. Ghosh, S. Debnath, A. Bhattacharya, and P. B. Chatterjee, “Affinity studies of hemicyanine derived water soluble colorimetric probes with reactive oxygen/nitrogen/sulfur species”, ChemBioChem. 2023, 24, 202200541.
    • A. Bhattacharya, R. Ghosh, S. Debnath and P. B. Chatterjee, “A simple, selective, and rapid detection-cum-precipitation of hazardous gold nanoparticles and their discrimination from gold(III) in environmental samples by a chromofluorogenic probe”, Sens. Actuat B. Chem. 2023, 378, 133158.
    • R. Ghosh, S. Debnath, A. Bhattacharya, D. Pradhan and P. B. Chatterjee, “Studies on the interaction between oxido/dioxidovanadium (V) compounds and reactive oxygen species: Synthesis, characterization, and photophysical investigation” J. Inorg. Biochem., 2022, 233, 111845.
    • R. R. Nair, M. Raju, S. Debnath, R. Ghosh and P. B. Chatterjee, “Concurrent detection and treatment of cyanide-contaminated water using mechanosynthesized receptors” Analyst. 2020, 145, 5647-5656.
    • R. R. Nair, S. Debnath, S. Das, P. Wakchaure, B. Ganguly and P. B. Chatterjee, “A highly selective turn-on biosensor for measuring spermine/spermidine in human urine and blood” ACS Appl. Bio Mater. 2019, 2, 2374-2387.
    • M. Raju, R. R. Nair, S. Debnath,and P. B. Chatterjee, “Affinity directed surface functionalization of two different metal nanoparticles by a natural ionophore: probing and removal of Hg2+ and Al3+ ions from aqueous solutions” Inorg. Chem. 2019, 58, 1674-1683.

Zhi Chen (Research Professor)

Research interest

Light-controlled drug delivery, Optoelectronic biosensing

Contact
office
Asan Sci. 548B
E-mail
alexchen017010913@yahoo.com
Publications
  • Z. Chen, J. Li, T. Li, et al., ‘A CRISPR/Cas12a empowered Surface Plasmon Resonance Platform for Rapid and Specific Diagnosis of the Omicron Variant of SARS-CoV-2.’ Nat. Sci. Rev., 2022, 9, 8
  • Z. Chen, C. Meng, X. Wang, et al., ‘Ultrasensitive DNA Origami Plasmon Sensor for Accurate Detection in Circulating Tumor DNAs.’ Laser Photonics Rev., 2024, Read here
    • MORE VIEW
    • Z. Chen, C. Wu, Y. Yuan, et al., ‘CRISPR-Cas13a-powered electrochemical biosensor for the detection of the L452R mutation in clinical samples of SARS-CoV-2 variants.’ J. Nanobiotechnology, 2023, 21, 141.
    • Z. Chen, H. Huang, J. Deng, et al., ‘Light-guided Genetic Scissors Based on Phosphorene Quantum Dot.’ Laser Photonics Rev., 2024, Read here
    • J. Chen, Z. Chen, C. Meng, et al., ‘CRISPR-powered optothermal nanotweezers: Diverse bio-nanoparticle manipulation and single nucleotide identification.’ Light Sci. Appl., 2023, 12, 273.
    • F. Zheng, Z. Chen, J. Li, et al., ‘A Highly Sensitive CRISPR-Empowered Surface Plasmon Resonance Sensor for Diagnosis of Inherited Diseases with Femtomolar-Level Real-Time Quantification.’ Adv. Sci., 2022, 9, 14, e2105231
    • Y. Chen, Z. Chen, T. Li, et al., ‘Ultrasensitive and Specific Clustered Regularly Interspaced Short Palindromic Repeats Empowered a Plasmonic Fiber Tip System for Amplification-Free Monkeypox Virus Detection and Genotyping.’ ACS Nano, 2023, 17, 12903-12914
    • J. Shen, Z. Chen, R. Xie, et al., ‘CRISPR/Cas12a-Assisted Isothermal Amplification for Rapid and Specific Diagnosis of Respiratory Virus on an Microfluidic Platform.’ Biosens. Bioelectron., 2023, 237, 115523
    • C. Wu, Z. Chen, C. Li, et al., ‘CRISPR-Cas12a-Empowered Electrochemical Biosensor for Ultrasensitive Detection of SARS-CoV-2 Delta Variant.’ Nanomicro Lett., 2022, 14, 1, 159
    • X. Wang, X. Han, C. Li, Z. Chen, et al., ‘2D Materials for Bone Therapy.’ Adv. Drug Deliv. Rev., 2021, 178, 1, 113970

이민구 (Min-Goo Lee) (Research Professor)

Research interest

Protein Degradation, Regulation of Tumor stress

Contact
office
Asan Sci. 123A
E-mail
mglee @ korea.ac.kr
Publications
  • M.-G. Lee, Z. Choi, N.-J. Lim, J.-S. Lim, K.-W. Lee, K.-P. Ko, B.-K. Ryu, S.-H. Kang, S.-G. Chi*‎, ‘XAF1 directs glioma response to temozolomide through apoptotic transition of autophagy by activation of ATM–AMPK signaling’ Neurooncol Adv. 2022, 4, 1, vdac013. Read here
  • S. Koo, M.-G. Lee, A. Sharma, M. Li, X. Zhang, K. Pu*, S.-G. Chi*, J. S. Kim*, ‘Harnessing GLUT1-Targeted Pro-oxidant Ascorbate for Synergistic Phototherapeutics’ Angew. Chem. Int. Ed 2022, 61, 17, e202110832. Read here
    • MORE VIEW
    • A. Sharma, M.-G. Lee, M. Won, S. Koo, J. F. Arambula, J. L. Sessler*, S.-G. Chi*, and J. S. Kim*, ‘Targeting Heterogeneous Tumors Using a Multifunctional Molecular Prodrug’ J. Am. Chem. Soc. 2019, 141, 39, 15611-15618. Read here
    • A. Sharma, M.-G. Lee, H. Shi, M. Won, J. F. Arambula, J. L. Sessler*, J. Y. Lee*, S.-G. Chi*, J. S. Kim*, ‘Overcoming Drug Resistance by Targeting Cancer Bioenergetics with an Activatable Prodrug’ Chem 2018, 4, 10, 2370-2383. Read here
    • M.-G. Lee, S.-I. Jeong, K.-P. Ko, S.-K. Park. B.-K. Ryu, I.-Y. Kim, J.-K. Kim, S.-G. Chi*, ‘RASSF1A Directly Antagonizes RhoA Activity through the Assembly of a Smurf1-M’ Cancer Res. 2016, 76, 7, 1847-1859. Read here
    • M.-G. Lee, J. Han, S.-I. Jeong, N.-G. Her, J.-H. Lee, T.-K. Ha, M.-J. Kang, B.-K. Ryu, S.-G. Chi*, ‘XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313’ Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 43, 15532-15537. Read here

Jun Li (Research Professor)

Research interest

Supramolecular theranostics

Contact
office
Asan Sci. 548B
E-mail
ljhbnu at 163.com
Publications
  • S. Asghar, Z. Yu, Z. Zhu, D. Zheng, Z. Zhao, Y. Xu, X. Liu, C. Yuan, Y. Li, W. Wang, J. Xu, H. Teng, J. Li*, W-C. Yang*, C. Chen*. Visualization of Hg2+ stress on plant health at the subcellular level revealed by a highly sensitive fluorescent sensor. Research, 2025, 8, Article0570. Read here
  • Y-Y. Cao, J. He, X-H. Li, J-H. Li, H. Wu, T. Wen, J. Li*, G-F. Hao*, J. Yoon*. Fluorescent chemosensors facilitate the visualization of plant health and their living environment in sustainable agriculture. Chem. Soc. Rev., 2024, 53, 6992-7090. Read here
    • MORE VIEW
    • J. Du, K. Chen, Z. Yu, Y. Qiao, X. Liu, Q. Zhai, S. Yang, J. Li**, H. Teng*. Development of bi-oligo (ethylene glycol)-functionalized fluorescent probe for two-photon and noninvasive fluorescence imaging in Arabidopsis thaliana. Adv. Agrochem, 2022, 1, 162-173. This paper is dedicated to the 60th anniversary of the pesticide discipline of Central China Normal University)
    • J. Li, L. Tu, Q. Ouyang, S. Yang, X. Liu, Q. Zhai, Y. Sun, J. Yoon, H. Teng. A coumarin-based fluorescent probe for NIR imaging-guided photodynamic therapy against S. aureus-induced infection in mouse models. J. Mater. Chem. B, 2022, 10, 1427-1433.
    • J. Li, Y. Zhang, P. Wang, Le. Yu, J. An, G. Deng, Y. Sun, J. S. Kim. Reactive oxygen species, thiols and enzymes activable AIEgens from single fluorescence imaging to multifunctional theranostics. Coord. Chem. Rev. 2021, 427, 213559.
    • J. Li, Y. Liu, Y. Xu, L. Li, Y. Sun, W. Huang. Recent advances in the development of NIR-II organic emitters for biomedicine. Coord. Chem. Rev. 2020, 415, 213318.
    • J. Li, Y. Cui, C. Bi, S. Feng, F. Yu, E. Yuan, S. Xu, Z, Hu, Q. Sun, D. Wei, J. Yoon. Oligo (ethylene glycol)-Functionalized Ratiometric Fluorescent Probe for the Detection of Hydrazine in Vitro and in Vivo. Anal. Chem., 2019, 91, 7360-7365.
    • J. Li，D-J. Yim, W-D. Jang and J. Yoon. Recent Progress in the Design and Applications of Fluorescence Probes Containing Crown Ethers. Chem. Soc. Rev., 2017, 46, 2437-2458. (Front Cover Paper)
    • J. Li，N, Kwon, Y. Jeong, S, Lee, G, Kim, J. Yoon. Aggregation-Induced Fluorescence Probe for Monitoring Membrane Potential Changes in Mitochondria. ACS Appl. Mater. Interfaces. 2018, 15, 12150-12154.
    • J. Li, C. S. Lim, G. Kim, H. M. Kim, J. Yoon. Highly Selective and Sensitive Two-Photon Fluorescence Probe for Endogenous Peroxynitrite Detection and Its Applications in Living Cells and Tissues. Anal. Chem., 2017, 89, 8496-8500.

Rakesh Mengji (Research Professor)

Research interest

Photoresponsive drug delivery system & bio-imaging system

Contact
office
Asan Sci. 337
E-mail
rakesh.iict15 at gmail.com
Publications
  • R. Mengji, C. Acharya, V. Vangala, A. Jana*, ‘A Lysosome Specific Near-Infrared Fluorescent Probe for the in vitro Cancer Cell Detection and Non-Invasive in vivo Imaging’ Chem. Commun. 2019, 55, 14182. Read here
  • R. Mengji, D. Paladugu, B. Saha*, A. Jana*, ‘Single-Photon Deep-Red Light-Triggered Direct Release of an Anticancer Drug: An Investigative Tumor Regression Study on Breast Cancer Spheroidal-Tumor Model’ J. Med. Chem. 2024, 67, 13, 3650–3661. Read here
    • MORE VIEW
    • A. K. Singh#, R. Mengji#, A. V. Nair, S. S. Shah, A. Jana*, N. D. P. Singh*, ‘Photoactivable AIEgen-based Lipid-Droplet-Specific Drug Delivery Model for Live Cell Imaging and Two-Photon Light-Triggered Anticancer Drug Delivery’ ACS Appl. Bio Mater. 2023, 6, 4372. Read here
    • P. K. Singh#, R. Mengji#, S. Kumar, A. K. Singh, A. Jana*, S. P. Singh, ‘BODIPY-Based Mitochondrial Targeted NIR-Responsive CO-Releasing Platform for the On-Demand Release of CO to Treat Cancer’ ACS Appl. Bio Mater. 2023, 6, 3778. Read here
    • A. Sikder, R. Mengji, S. Mondal, A. Jana*, N. D. P. Singh*, ‘Spatiotemporal Photo-Release of Hydrogen Sulfide from β-Carboline-Derived Nanoparticles for Therapeutic Applications’ J. Mater. Chem. B 2023, 11, 5131. Read here
    • B. Roy, R. Mengji, S. Roy, B. Pal, A. Jana*, N. D. P. Singh*, ‘NIR-Responsive Lysosomotropic Phototrigger: An ‘AIE + ESIPT’ Active Naphthalene-Based Single-Component Photoresponsive Nanocarrier with Two-Photon Uncaging and Real-Time Monitoring Ability’ ACS Appl. Mater. Interfaces 2022, 14, 4862. Read here
    • Y. Venkatesh#, V. Vangala#, R. Mengji, A. Chaudhuri, S. Bhattacharya, P. K. Datta, R. Banerjee, A. Jana*, A. Anoop*, N. D. P. Singh*, ‘One- and Two-Photon Uncaging of Carbon Monoxide (CO) with Real-Time Monitoring: On-Demand Carbazole-Based Dual CO-Releasing Platform to Test over Single and Combinatorial Approaches for the Efficient Regression of Orthotopic Murine Melanoma In Vivo’ J. Med. Chem. 2022, 65, 1822. Read here
    • A. Paul, R. Mengji, M. Bera, M. Ojha, A. Jana*, N. D. P. Singh*, ‘Mitochondria-Localized In Situ Generation of Rhodamine Photocage with Fluorescence Turn-On Enabling Cancer Cell-Specific Drug Delivery Triggered by Green Light’ Chem. Commun. 2020, 56, 8412. Read here
    • A. Chaudhuri, R. Mengji, Y. Venkatesh, A. Jana*, N. D. P. Singh*, ‘An Improved Tumor-Specific Therapeutic Strategy by the Spatio-Temporally Controlled In Situ Formation of a Cu(II) Complex, Leading to Prompt Cell Apoptosis via Photoactivation of a Prodrug’ Chem. Commun. 2020, 56, 4559. Read here
    • M. Gangopadhyay, R. Mengji, A. Paul, Y. Venkatesh, V. Vangala, A. Jana*, N. D. P. Singh*, ‘Redox-Responsive Xanthene–Coumarin–Chlorambucil-Based FRET-Guided Theranostics for \'Activatable\' Combination Therapy with Real-Time Monitoring’ Chem. Commun. 2017, 53, 9109. Read here
    • A. Paul, R. Mengji, O. A. Chandy, S. Nandi, M. Bera, A. Jana*, A. Anoop*, N. D. P. Singh*, ‘ESIPT-Induced Fluorescent o-Hydroxycinnamate: Self-Monitoring Phototrigger for Prompt Image-Guided Uncaging of Alcohols’ Org. Biomol. Chem. 2017, 15, 8544. Read here
    • S. Biswas, R. Mengji, S. Barman, V. Vangala, A. Jana*, N. D. P. Singh*, ‘‘AIE + ESIPT’ Assisted Photorelease: Fluorescent Organic Nanoparticles for Dual Anticancer Drug Delivery with Real-Time Monitoring Ability’ Chem. Commun. 2018, 54, 168. Read here


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