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Snehasish Debnath (Research Professor)

Research interest

Bioorthogonal Chemistry, Neuro-degenerative Disease, PDT, Drug delivery system,

Contact
office
Asan Sci. 548B
E-mail
snehasish14 at gmail.com
Publications
  • J. Kim‡, S. Debnath‡, E. Kim, C. Yoon, J. Seo, S. Hua and J. S. Kim*, “Tetrazine Mediated Bioorthogonally Activated Therapeutic (TBAT) Platform”, J. Am. Chem. Soc. 2026, 148, 9169-9184.
  • S. Debnath, J. Yoo, Y. Kim, J. Kim, K. Lee, P. B. Chatterjee*, and J. S. Kim*, “Metalloprobes for Gasotransmitters/Biothiols Linked Diseases-Innovation to Implementation”, Chem. Soc. Rev., 2026 (in press).
  • J. Kim, Y. Lee, Y. Kim, H. Rha, D. Kim, S. Debnath*, K. Pu*, H. Kang*, and J. S. Kim*, “Site-specific transformable nanostructures for cancer therapy and diagnosis”, Chem. Rev. 2025, 125, 9012-9052.
    • MORE VIEW
    • J. Li‡, E. Pang‡, S. Debnath‡, J. Hong‡, A. Qiu, D. Kim, G. Kim, M. Lan, M.G. Lee, Q. Y. Cao, and J. S. Kim*, “Self-immolative Activatable Nanoassembly toward Immuno-Photodynamic Therapy in TME”, Adv. Funct. Mater. 2025, e13250.
    • C. Wang, F. Yuan, C. Fu, Y. Li, G. Dai, H. S. Kim, S. Xia, L. Yu, S. Debnath, W. X. Ren*, J. Shu*, M. Qiu*, J. S. Kim*, ‘High Entropy 2D Layered Double Hydroxides Nanosheet Toward Unprecedented Cascaded Nanozyme-Initiated Chemodynamic and Immune Synergistic Therapy’ J. Am. Chem. Soc. 2025, 147, 136-148.
    • S. Mondal, J. An, T. Bera, M. Banerjee, S. Debnath, D. Mandal, A. Sikder, S. Guha*, J. S. Kim* and N. D. Pradeep*, “Engineering a GFP-core-inspired NIR-photocage: Exploring meso-GFP-PRPG towards Alzheimer\'s Disease therapeutics”, ACS. Cent. Sci., 2025, 11, 1062-1070.
    • J. An, K. P. Lv, C. V. Chau, J. H. Lim, R. Parida, X. Huang, S. Debnath, Y. Xu, S. Zheng, A. C. Sedgwick, J. Y. Lee, D. Luo*, Q. Liu*, J. L. Sessler*, and J. S. Kim*, “Lutetium texaphyrin-celecoxib conjugate as a potential immuno-photodynamic therapy agent”, J. Am. Chem. Soc. 2024, 146, 28, 19434-19448.
    • Zhang, B. Guo, Y. Jiang, C. Hu, J. Kim, S. Debnath, X. Shi, C. Zhang, J. S. Kim*, and F. Wang*, “Luciferase-decorated gold nanorods as dual-modal contrast agents for tumor-targeted high-performance bioluminescence/photoacoustic imaging”, Anal. Chem. 2024, 96, 9132-9140.
    • S. Debnath, S. S. Paramasivam, D. Pradhan, P. Manickam and P. B. Chatterjee, “A redox-active copper complex for orthogonal detection of homocysteine involving fluorescence and electrochemical techniques”, Small 2025, 21, 2409982.
    • R. Ghosh, D. Pradhan, S. Debnath, A. Mansingh, N. Nagesh, and P. B. Chatterjee, “A hydrogen-bonded non-porous organic inorganic framework for measuring cysteine in blood plasma and endogenous cancer cell”, Chem. Eur. J. 2024, 30, e202401255.
    • R. Ghosh, R. R. Nair, S. Ghosh, S. Debnath, and P. B. Chatterjee, “A water-soluble wavy coordination polymer of Cu (II) as a turn-on luminescent probe for histidine and histidine-rich proteins/peptides”, Inorg. Chem. 2024, 63, 8320-8328.
    • R. Ghosh, S. Luhar, S. Debnath, K. B. Patel, K. Baskaran, D. N. Srivastava and P. B. Chatterjee, “Measurement of the malignancy marker spermine in human biofluids using smartphone readout and impedance techniques: Analytical validation using HPLC”, Sens. Actuat B. Chem. 2024, 406, 135390.
    • R. R. Nair, S. Debnath, R. Ghosh, A. Bhattacharya, M. Raju, and P. B. Chatterjee, “Label-free detection of unbound bilirubin and nitrophenol explosives in water by a mechanosynthesized dual functional zinc complex: Recognition of picric acid in various common organic media”, Chem. Eur. J., 2024, 30, e202303068.
    • S. Debnath, R. Ghosh, Pragti, S. Mukhopadhyay, K. Baskaran and P. B. Chatterjee, “Fabrication of paper-based facile and low-cost microfluidic device and digital imaging technique for point-of-need monitoring of hypochlorite”, Analyst, 2023, 148, 4072-4083.
    • S. Debnath, S. V. Navadiya, R. Ghosh, D. Pradhan and P. B. Chatterjee, “Coumarin-ensembled vanadium(V) compounds and their affinity studies toward biological thiols probed by fluorescence spectroscopy”, Chem. Asian J., 2023, 18, 202201162.
    • S. Debnath, R. Ghosh, R. R. Nair, D. Pradhan and P. B. Chatterjee, “Advances in the development of water-soluble fluorogenic probes for bioimaging of hypochlorite/hypochlorous acid in cells and organisms”, ACS Omega, 2022, 43, 38122-38149.
    • S. Debnath, R. R. Nair, R. Ghosh, K. Gaddam, N. Radhakishan, N. Nagesh and P. B. Chatterjee, “A unique water soluble probe for measuring the cardiac marker homocysteine and its clinical validation” Chem. Commun., 2022, 58, 9210-9213.
    • S. Debnath, and P. B. Chatterjee, “Enantiopure chiroptical probes for circular dichroism and absorbance based detection of nerve gas simulants” Chem. Commun., 2022, 58, 9006-9009.
    • S. Debnath, R. R. Nair, R. Ghosh, A. Bhattacharya, and P. B. Chatterjee, “Smartphone assisted chromogenic sensing of halogenated solvents and monoaromatic hydrocarbons” Dyes Pigm. 2021, 196, 109821.
    • S. N. Bhaduri, D. Ghosh, S. Debnath, R. Biswas, P. B. Chatterjee, and P. Biswas, “Copper(II)-incorporated porphyrin based porous organic polymer for a nonenzymatic electrochemical glucose sensor’, Inorg. Chem. 2023, 62, 4316-4146.
    • R. Ghosh, S. Debnath, A. Bhattacharya, and P. B. Chatterjee, “Affinity studies of hemicyanine derived water soluble colorimetric probes with reactive oxygen/nitrogen/sulfur species”, ChemBioChem. 2023, 24, 202200541.
    • A. Bhattacharya, R. Ghosh, S. Debnath and P. B. Chatterjee, “A simple, selective, and rapid detection-cum-precipitation of hazardous gold nanoparticles and their discrimination from gold(III) in environmental samples by a chromofluorogenic probe”, Sens. Actuat B. Chem. 2023, 378, 133158.
    • R. Ghosh, S. Debnath, A. Bhattacharya, D. Pradhan and P. B. Chatterjee, “Studies on the interaction between oxido/dioxidovanadium (V) compounds and reactive oxygen species: Synthesis, characterization, and photophysical investigation” J. Inorg. Biochem., 2022, 233, 111845.
    • R. R. Nair, M. Raju, S. Debnath, R. Ghosh and P. B. Chatterjee, “Concurrent detection and treatment of cyanide-contaminated water using mechanosynthesized receptors” Analyst. 2020, 145, 5647-5656.
    • R. R. Nair, S. Debnath, S. Das, P. Wakchaure, B. Ganguly and P. B. Chatterjee, “A highly selective turn-on biosensor for measuring spermine/spermidine in human urine and blood” ACS Appl. Bio Mater. 2019, 2, 2374-2387.
    • M. Raju, R. R. Nair, S. Debnath,and P. B. Chatterjee, “Affinity directed surface functionalization of two different metal nanoparticles by a natural ionophore: probing and removal of Hg2+ and Al3+ ions from aqueous solutions” Inorg. Chem. 2019, 58, 1674-1683.

이민구 (Min-Goo Lee) (Research Professor)

Research interest

Targeted Protein Degradation (TPD), Translational Cancer Research

Contact
office
Asan Sci. 123A
E-mail
mglee @ korea.ac.kr
Publications
  • Ji Hyeon Kim†, Bryan Yat Kit Hui†, Jieun Lee†, Kyeong-woo Lee, Jungryun Kim, Yujin Kim, Ming Hui Chua, Jianwei Xu, M.-G. Lee*, Xiaogang Liu*, Jong Seung Kim *, ‘PET-leveraged ALDH probe toward cancer stem cells’ Journal of Materials Chemistry B. 2025, 6, 3. Read here
  • Jing Li, E Pang, Snehasish Debnath, Jia Hong, Aojun Qiu, Dongeun Kim, Goeun Kim, Minhuan Lan, M.-G. Lee*, Qian-Yong Cao*, Jong Seung Kim*, ‘Self-Immolative Activatable Nanoassembly toward Immuno-Photodynamic Therapy in TME’ Advanced Functional Materials 2025, 09, 36, 14. Read here
    • MORE VIEW
    • Huiling Lin, Zhi Chen*, Changyu Yoon, Yubin Lee, Seokjin Hong, Jiwoo Seo, Xiangjiang Wang, M.-G. Lee*, Jong Seung Kim*, ‘Exciton-plasmon coupling in tBLG-Au nanodisks for ultrasensitive miRNA sensing’ National Science Review 2025. 11, 12, 12, Read here
    • Seung-Hun Jang, Hwi-Wan Choi, Jieun Ahn, Sungchan Jang, Ji-Hye Yoon, M.-G. Lee, Sung-Gil Chi*, ‘XAF1 antagonizes TRIM28 activity through the assembly of a ZNF313-mediated destruction complex to suppress tumor malignancy’ Molecular Biomedicine. 2024. 11, 5, 58, 1847-1859. Read here
    • Jieun Ahn, Seung-Hun Jang, Sungchan Jang, Ji-Hye Yoon, M.-G. Lee, S.-G. Chi*, ‘XAF1 is secreted from stressed tumor cells to activate T cell-mediated tumor surveillance via Lck-ERK signaling’ Neoplasia 2024. 11, 59, 1-11. Read here
    • M.-G. Lee, Z. Choi, N.-J. Lim, J.-S. Lim, K.-W. Lee, K.-P. Ko, B.-K. Ryu, S.-H. Kang, S.-G. Chi*‎, ‘XAF1 directs glioma response to temozolomide through apoptotic transition of autophagy by activation of ATM–AMPK signaling’ Neurooncol Adv. 2022, 4, 1, vdac013. Read here
    • S. Koo, M.-G. Lee, A. Sharma, M. Li, X. Zhang, K. Pu*, S.-G. Chi*, J. S. Kim*, ‘Harnessing GLUT1-Targeted Pro-oxidant Ascorbate for Synergistic Phototherapeutics’ Angew. Chem. Int. Ed 2022, 61, 17, e202110832. Read here

Yuling Xu (Research Professor)

Research interest

Bioimaging, Phototheranostics

Contact
office
Asan Sci. 337
E-mail
xuyuling.chem at gmail.com
Publications
  • Y. Xu, C. Li, J. An, X. Ma, J. Yang, L. Luo, Y. Deng, J. S. Kim, Y. Sun, ‘Construction of a 980 nm laser-activated Pt(II) metallacycle nanosystem for efficient and safe photo-induced bacteria sterilization’ Sci. China. Chem. 2023, 66, 155. Read here
  • Y. Xu, Y. Zhang, J. Li, J. An, C. Li, S. Bai, A. Sharma, G. Deng, J. S. Kim, Y. Sun, ‘NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens’ Biomaterials 2020, 259, 120315. Read here
    • MORE VIEW
    • Y. Xu, C. Li, X. Ma, W. Tuo, L. Tu, X. Li, Y. Sun, P. J. Stang, Y. Sun, ‘Long wavelength–emissive Ru(II) metallacycle-based photosensitizer assisting in vivo bacterial diagnosis and antibacterial treatment’ Proc. Natl. Acad. Sci. USA 2022, 119, e2209904119. Read here
    • Y. Xu, C. Li, S. Lu, Z. Wang, S. Liu, X. Yu, X. Li, Y. Sun, ‘Construction of emissive ruthenium(II) metallacycle over 1000 nm wavelength for in vivo biomedical applications’ Nat. Commun. 2022, 13, 2009. Read here
    • Y. Xu, Y. Pang, L. Luo, A. Sharma, J. Yang, C. Li, S. Liu, J. Zhan, Y. Sun, ‘De Novo Designed Ru(II) Metallacycle as a Microenvironment-Adaptive Sonosensitizer and Sonocatalyst for Multidrug-Resistant Biofilms Eradication’ Angew. Chem. Int. Ed. 2024, 63, e202319966. Read here

Qihang Ding

Research interest

Fabrication of organic small molecule probes in the NIR-II

Contact
office
Asan sci. 238
E-mail
dingqihang at whu.edu.cn
Publications
  • Q. Li, Q. Ding, Y. Li, X. Zeng, Y. Liu, S. Lu, H. Zhou, X. Wang, J.Wu, X. Meng, Z. Denga and Y. Xiao ‘Novel small-molecule fluorophores for in vivo NIR-IIa and NIR-IIb imaging’ Chemical Communications. doi:10.1039/c9cc09865h
  • Y. Li, Y. Liu, Q. Li, X. Zeng, T. Tian, W.Zhou, Y. Cui, X. Wang, X. Cheng, Q. Ding, X. Wang, J. Wu, H. Deng, Y. Li, X. Meng, Z. Deng, X. Honga, and Y. Xiao ‘Novel NIR-II organic fluorophores for bioimaging beyond 1550 nm’ Chemical Science. doi:10.1039/c9sc06567a
  • H. Zhou, W. Yi, A. Li, B. Wang, Q. Ding, L. Xue, X. Zeng, Y. Feng, Q. Li, T. Wang, Y. Li, X. Cheng, L. Tang, Z. Deng, M. Wu, Y. Xiao, and X. Hong ‘Specific Small‐Molecule NIR‐II Fluorescence Imaging of Osteosarcoma and Lung Metastasis’ Advanced Healthcare Materials. doi:10.1002/adhm.201901224
    • MORE VIEW
    • J. Lin, Q. Li, X. Zeng, Z. Chen, Q. Ding, Y. Li, H. Zhou, X. Meng, D. Chen, Z. Deng, X. Hong and Y. Xiao ‘A novel small-molecule near-infrared II fluorescence probe for orthotopic osteosarcoma imaging’ SCIENCE CHINA Chemistry 63, 766 (2020); doi: 10.1007/s11426-019-9685-6

김정륜 (Jungryun Kim)

Research interest

Bioorthogonal Chemistry, Phototherapeutics

Contact
office
Asan Sci. 238
E-mail
ryunnkim at korea.ac.kr
Publications
  • J. Kim†, S. Debnath†, E. Kim, C. Yoon, J. Seo, S. Hua, J. S. Kim*, ‘Tetrazine Mediated Bioorthogonally Activated Therapeutic (TBAT) Platform’ J. Am. Chem. Soc. 2026 (ASAP). Read here

  • J. Kim†, Y. Lee†, Y. Kim†, H. Rha, D. Kim, S. Debnath, K. Pu*, H. Kang*, J. S. Kim*, ‘Site-specific transformable nanostructures for cancer therapy and diagnosis’ Chem. Rev. 2025 125, 9012. Read here

    • MORE VIEW
    • J. Kim†, C. Hu†, P. Jangili, C. Tang*, F. Wang*, J. S. Kim*, ‘Dexamethasone-appended activatable prodrug overcoming multidrug resistance’ J. Med. Chem. 2025, 68, 23589-23597​. Read here

    • J. H. Kim, B. Y. K. Hui, Ji. Lee, K.-w. Lee, J. Kim, Y. Kim, M. H. Chua, J. Xu, M.-G. Lee, X. Liu, J. S. Kim, ‘PET-leveraged ALDH probe toward cancer stem cells’ J. Mat. Chem. B 2025 13, 11809. Read here

    • Q. Ding, J. Liu, Y. Wang, J. Kim, Z. Huang, Y. Lee, H. Zhou, P. Zhang, J. L. Sessler, J. S. Kim, ‘Dual-laser ‘808 and 1064 nm’ strategy that circumvents the Achilles’ heel of photothermal therapy’ PNAS 2025 122, e2503574122. Read here

    • S. Chen†, G. Yuan†, L. Wang†, J. Kim†, H. Wang, J. Yoo, F. Cao, X. Lin, H. Huang, J. S. Kim, H. Xia, P. Zhang, ‘Metalla-Aromatic Oligomers: Efficient Photocatalytic Activation for Phototherapy’ J. Med. Chem. 2025, 68, 11, 11841-11851. Read here

    • J. Gong†, Q. Ding†, Y. Shi, M. Li, C. Liu, W. Zeng, J. Kim, S. Shan, W. Zhang, M. Qi*, J. S. Kim*‎, ‘NIR-responsive gold nanomaterials in photothermal antibacterial therapy: From morphological design to multifunctional platforms’ Coord. Chem. Rev. 2024, 526, 216348. Read here
    • J. Kim†, Y. Xu†*, J. H. Lim†, J. Y. Lee*, M. Li*, J. M. Fox*, M. Vendrell*, J. S. Kim*, ‘Bioorthogonal Activation of Deep Red Photoredox Catalysis Inducing Pyroptosis’ J. Am. Chem. Soc. 2025, 147, 701-712. Read here
    • K. Dou†, J. Lu†, Y. Xing, R. Wang, M. Won, J. Kim, F. Yu*, J. S. Kim*, ‘Metabolic Acidity/H2O2 Dual-Cascade-Activatable Molecular Imaging Platform toward Metastatic Breast Tumor Malignancy’ Angew. Chem. Int. Ed. 2024, e202419191. Read here
    • Y. Xu†, J. Kim, H. Rha, J. S. Kim*, ‘Oxidative photocatalysis on intracellular on intracellular membranes lights up Photopyro’ Matter 2024, 7, 3253-3255. Read here
    • F. Mehvari†, V. Ramezanzade†, J. An, J. Kim, M. Dinari*, J. S. Kim*‎, ‘Biopolymer-based hydrogels for biomedical applications: bioactivity and wound healing properties’ Coord. Chem. Rev. 2024, 518, 216093. Read here
    • B. Zhu†, X. Xing, J. Kim, H. Rha, C. Liu, Q. Zhang, L. Zeng*, M. Lan*, J. S. Kim*, ‘Endogenous CO imaging in bacterial pneumonia with a NIR fluorescent probe’ Biomaterials 2023, 304, 122419. Read here
    • S. Lee, J. Yoo, G. Bae, R. Thangam, J. Heo, J. Y. Park, H. Choi, C. Kim, J. An, J. Kim, K. R. Mun, S. Shin, K. Zhang, P. Zhao, Y. Kim, N. Kang, S.-B. Han, D. Kim, J. Yoon, M. Kang, J. Kim, L. Yang, S. Karamikamkar, J. Kim, Y. Zhu, A. H. Najafabadi, D.-H. Kim, K.-B. Lee, S. J. Oh, H.-C. Song, W. Y. Jang, L. Bian, Z. Chu, J. S. Kim, Y. S. Zhang, Y. Kim, H. S. Jang*, S. Kim*, H. Kang*, ‘Photonic control of ligand nanospacing in self-assembly regulates stem cell fate’ Bioact. Mater., 2024, 34, 164-180. Read here
    • J. Kim†, P. Jangili†*, J. Kim†, S. Lucia, J. Ryu, R. Prasad, S. Zi, P. Kim*, W. Sun*, J. S. Kim*, ‘Mitochondrial NIR imaging probe mitigating oxidative damage by targeting HDAC6’ Chem. Commun. 2023, 59, 10109-10112. Read here
    • Z. Mao†, H. Rha†, J. Kim†, X. You, F. Zhang*, W. Tao*, J. S. Kim*, ‘THQ-Xanthene: An Emerging Strategy to Create Next-Generation NIRI/II Fluorophores’ Adv. Sci. 2023, 10, 2301177. Read here
    • M. Li†, J. Kim†, H. Rha, S. Son, Y. Xu*, J. L. Sessler*, J. S. Kim*, ‘Photon-Controlled Pyroptosis Activation (PhotoPyro): An Emerging Trigger for Antitumor Immune Response’ J. Am. Chem. Soc. 2023, 145, 6007-6023. Read here
    • L. Yu†, Y. Xu, J. Kim, J. Lee, J. S. Kim*, ‘A rational design of AIE-active fluorophore for the fingerprint optical detection’ Bull. Korean Chem. Soc. 2023, 44, 516-522. Read here
    • M. Li†, J. Kim, Y. Xu, J. S. Kim*, ‘An acid-activatable nanosensitizer library realizes tunable pyroptosis activation in tumors’ Matter 2023, 6, 15-18. Read here
    • J. Shin†, N. Kang†, B. Kim†, H. Hong, L. Yu, J. Kim, H. Kang*, J. S. Kim*, ‘ One-dimensional nanomaterials for cancer therapy and diagnosis’ Chem. Soc. Rev. 2023, 52, 4488. Read here
    • N. Singh†, J. Kim†, J. Kim†, K. Lee†, Z. Zunbul, I. Lee, S. G. Chi*, J. S. Kim*, ‘Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications’ Bioact. Mater. 2023, 21, 358-380. Read here
    • S. Son†, J. Kim†, J. Kim, B. Kim, J. Lee, Y. Kim, M. Li*, H. Kang*, J. S. Kim*, ‘Cancer therapeutics based on diverse energy sources’ Chem. Soc. Rev. 2022, 51, 8201-8215. Read here
    • H. Chu, L. Yang, L. Yu, J. Kim, J. Zhou*, M. Li*, J. S. Kim*, ‘Fluorescent probes in public health and public safety’ Coord. Chem. Rev. 2021 449, 214208. Read here


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