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Snehasish Debnath (Research Professor)

Research interest

Bioorthogonal Chemistry, Neuro-degenerative Disease, PDT, DDS

Contact
office
Asan Sci. 548B
E-mail
snehasish14 at gmail.com
Publications
  • J. Kim‡, S. Debnath‡, E. Kim, C. Yoon, J. Seo, S. Hua and J. S. Kim*, “Tetrazine Mediated Bioorthogonally Activated Therapeutic (TBAT) Platform”, J. Am. Chem. Soc. 2026, 148, 9169-9184.
  • S. Debnath, J. Yoo, Y. Kim, J. Kim, K. Lee, P. B. Chatterjee*, and J. S. Kim*, “Metalloprobes for Gasotransmitters/Biothiols Linked Diseases-Innovation to Implementation”, Chem. Soc. Rev., 2026 (in press).
  • J. Kim, Y. Lee, Y. Kim, H. Rha, D. Kim, S. Debnath*, K. Pu*, H. Kang*, and J. S. Kim*, “Site-specific transformable nanostructures for cancer therapy and diagnosis”, Chem. Rev. 2025, 125, 9012-9052.
    • MORE VIEW
    • J. Li‡, E. Pang‡, S. Debnath‡, J. Hong‡, A. Qiu, D. Kim, G. Kim, M. Lan, M.G. Lee, Q. Y. Cao, and J. S. Kim*, “Self-immolative Activatable Nanoassembly toward Immuno-Photodynamic Therapy in TME”, Adv. Funct. Mater. 2025, e13250.
    • C. Wang, F. Yuan, C. Fu, Y. Li, G. Dai, H. S. Kim, S. Xia, L. Yu, S. Debnath, W. X. Ren*, J. Shu*, M. Qiu*, J. S. Kim*, ‘High Entropy 2D Layered Double Hydroxides Nanosheet Toward Unprecedented Cascaded Nanozyme-Initiated Chemodynamic and Immune Synergistic Therapy’ J. Am. Chem. Soc. 2025, 147, 136-148.
    • S. Mondal, J. An, T. Bera, M. Banerjee, S. Debnath, D. Mandal, A. Sikder, S. Guha*, J. S. Kim* and N. D. Pradeep*, “Engineering a GFP-core-inspired NIR-photocage: Exploring meso-GFP-PRPG towards Alzheimer\'s Disease therapeutics”, ACS. Cent. Sci., 2025, 11, 1062-1070.
    • J. An, K. P. Lv, C. V. Chau, J. H. Lim, R. Parida, X. Huang, S. Debnath, Y. Xu, S. Zheng, A. C. Sedgwick, J. Y. Lee, D. Luo*, Q. Liu*, J. L. Sessler*, and J. S. Kim*, “Lutetium texaphyrin-celecoxib conjugate as a potential immuno-photodynamic therapy agent”, J. Am. Chem. Soc. 2024, 146, 28, 19434-19448.
    • Zhang, B. Guo, Y. Jiang, C. Hu, J. Kim, S. Debnath, X. Shi, C. Zhang, J. S. Kim*, and F. Wang*, “Luciferase-decorated gold nanorods as dual-modal contrast agents for tumor-targeted high-performance bioluminescence/photoacoustic imaging”, Anal. Chem. 2024, 96, 9132-9140.
    • S. Debnath, S. S. Paramasivam, D. Pradhan, P. Manickam and P. B. Chatterjee, “A redox-active copper complex for orthogonal detection of homocysteine involving fluorescence and electrochemical techniques”, Small 2025, 21, 2409982.
    • R. Ghosh, D. Pradhan, S. Debnath, A. Mansingh, N. Nagesh, and P. B. Chatterjee, “A hydrogen-bonded non-porous organic inorganic framework for measuring cysteine in blood plasma and endogenous cancer cell”, Chem. Eur. J. 2024, 30, e202401255.
    • R. Ghosh, R. R. Nair, S. Ghosh, S. Debnath, and P. B. Chatterjee, “A water-soluble wavy coordination polymer of Cu (II) as a turn-on luminescent probe for histidine and histidine-rich proteins/peptides”, Inorg. Chem. 2024, 63, 8320-8328.
    • R. Ghosh, S. Luhar, S. Debnath, K. B. Patel, K. Baskaran, D. N. Srivastava and P. B. Chatterjee, “Measurement of the malignancy marker spermine in human biofluids using smartphone readout and impedance techniques: Analytical validation using HPLC”, Sens. Actuat B. Chem. 2024, 406, 135390.
    • R. R. Nair, S. Debnath, R. Ghosh, A. Bhattacharya, M. Raju, and P. B. Chatterjee, “Label-free detection of unbound bilirubin and nitrophenol explosives in water by a mechanosynthesized dual functional zinc complex: Recognition of picric acid in various common organic media”, Chem. Eur. J., 2024, 30, e202303068.
    • S. Debnath, R. Ghosh, Pragti, S. Mukhopadhyay, K. Baskaran and P. B. Chatterjee, “Fabrication of paper-based facile and low-cost microfluidic device and digital imaging technique for point-of-need monitoring of hypochlorite”, Analyst, 2023, 148, 4072-4083.
    • S. Debnath, S. V. Navadiya, R. Ghosh, D. Pradhan and P. B. Chatterjee, “Coumarin-ensembled vanadium(V) compounds and their affinity studies toward biological thiols probed by fluorescence spectroscopy”, Chem. Asian J., 2023, 18, 202201162.
    • S. Debnath, R. Ghosh, R. R. Nair, D. Pradhan and P. B. Chatterjee, “Advances in the development of water-soluble fluorogenic probes for bioimaging of hypochlorite/hypochlorous acid in cells and organisms”, ACS Omega, 2022, 43, 38122-38149.
    • S. Debnath, R. R. Nair, R. Ghosh, K. Gaddam, N. Radhakishan, N. Nagesh and P. B. Chatterjee, “A unique water soluble probe for measuring the cardiac marker homocysteine and its clinical validation” Chem. Commun., 2022, 58, 9210-9213.
    • S. Debnath, and P. B. Chatterjee, “Enantiopure chiroptical probes for circular dichroism and absorbance based detection of nerve gas simulants” Chem. Commun., 2022, 58, 9006-9009.
    • S. Debnath, R. R. Nair, R. Ghosh, A. Bhattacharya, and P. B. Chatterjee, “Smartphone assisted chromogenic sensing of halogenated solvents and monoaromatic hydrocarbons” Dyes Pigm. 2021, 196, 109821.
    • S. N. Bhaduri, D. Ghosh, S. Debnath, R. Biswas, P. B. Chatterjee, and P. Biswas, “Copper(II)-incorporated porphyrin based porous organic polymer for a nonenzymatic electrochemical glucose sensor’, Inorg. Chem. 2023, 62, 4316-4146.
    • R. Ghosh, S. Debnath, A. Bhattacharya, and P. B. Chatterjee, “Affinity studies of hemicyanine derived water soluble colorimetric probes with reactive oxygen/nitrogen/sulfur species”, ChemBioChem. 2023, 24, 202200541.
    • A. Bhattacharya, R. Ghosh, S. Debnath and P. B. Chatterjee, “A simple, selective, and rapid detection-cum-precipitation of hazardous gold nanoparticles and their discrimination from gold(III) in environmental samples by a chromofluorogenic probe”, Sens. Actuat B. Chem. 2023, 378, 133158.
    • R. Ghosh, S. Debnath, A. Bhattacharya, D. Pradhan and P. B. Chatterjee, “Studies on the interaction between oxido/dioxidovanadium (V) compounds and reactive oxygen species: Synthesis, characterization, and photophysical investigation” J. Inorg. Biochem., 2022, 233, 111845.
    • R. R. Nair, M. Raju, S. Debnath, R. Ghosh and P. B. Chatterjee, “Concurrent detection and treatment of cyanide-contaminated water using mechanosynthesized receptors” Analyst. 2020, 145, 5647-5656.
    • R. R. Nair, S. Debnath, S. Das, P. Wakchaure, B. Ganguly and P. B. Chatterjee, “A highly selective turn-on biosensor for measuring spermine/spermidine in human urine and blood” ACS Appl. Bio Mater. 2019, 2, 2374-2387.
    • M. Raju, R. R. Nair, S. Debnath,and P. B. Chatterjee, “Affinity directed surface functionalization of two different metal nanoparticles by a natural ionophore: probing and removal of Hg2+ and Al3+ ions from aqueous solutions” Inorg. Chem. 2019, 58, 1674-1683.

이민구 (Min-Goo Lee) (Research Professor)

Research interest

Targeted Protein Degradation (TPD), Translational Cancer Research

Contact
office
Asan Sci. 123A
E-mail
mglee @ korea.ac.kr
Publications
  • Ji Hyeon Kim†, Bryan Yat Kit Hui†, Jieun Lee†, Kyeong-woo Lee, Jungryun Kim, Yujin Kim, Ming Hui Chua, Jianwei Xu, M.-G. Lee*, Xiaogang Liu*, Jong Seung Kim *, ‘PET-leveraged ALDH probe toward cancer stem cells’ Journal of Materials Chemistry B. 2025, 6, 3. Read here
  • Jing Li, E Pang, Snehasish Debnath, Jia Hong, Aojun Qiu, Dongeun Kim, Goeun Kim, Minhuan Lan, M.-G. Lee*, Qian-Yong Cao*, Jong Seung Kim*, ‘Self-Immolative Activatable Nanoassembly toward Immuno-Photodynamic Therapy in TME’ Advanced Functional Materials 2025, 09, 36, 14. Read here
    • MORE VIEW
    • Huiling Lin, Zhi Chen*, Changyu Yoon, Yubin Lee, Seokjin Hong, Jiwoo Seo, Xiangjiang Wang, M.-G. Lee*, Jong Seung Kim*, ‘Exciton-plasmon coupling in tBLG-Au nanodisks for ultrasensitive miRNA sensing’ National Science Review 2025. 11, 12, 12, Read here
    • Seung-Hun Jang, Hwi-Wan Choi, Jieun Ahn, Sungchan Jang, Ji-Hye Yoon, M.-G. Lee, Sung-Gil Chi*, ‘XAF1 antagonizes TRIM28 activity through the assembly of a ZNF313-mediated destruction complex to suppress tumor malignancy’ Molecular Biomedicine. 2024. 11, 5, 58, 1847-1859. Read here
    • Jieun Ahn, Seung-Hun Jang, Sungchan Jang, Ji-Hye Yoon, M.-G. Lee, S.-G. Chi*, ‘XAF1 is secreted from stressed tumor cells to activate T cell-mediated tumor surveillance via Lck-ERK signaling’ Neoplasia 2024. 11, 59, 1-11. Read here
    • M.-G. Lee, Z. Choi, N.-J. Lim, J.-S. Lim, K.-W. Lee, K.-P. Ko, B.-K. Ryu, S.-H. Kang, S.-G. Chi*‎, ‘XAF1 directs glioma response to temozolomide through apoptotic transition of autophagy by activation of ATM–AMPK signaling’ Neurooncol Adv. 2022, 4, 1, vdac013. Read here
    • S. Koo, M.-G. Lee, A. Sharma, M. Li, X. Zhang, K. Pu*, S.-G. Chi*, J. S. Kim*, ‘Harnessing GLUT1-Targeted Pro-oxidant Ascorbate for Synergistic Phototherapeutics’ Angew. Chem. Int. Ed 2022, 61, 17, e202110832. Read here

Yuling Xu (Research Professor)

Research interest

Bioimaging, Phototheranostics

Contact
office
Asan Sci. 337
E-mail
xuyuling.chem at gmail.com
Publications
  • Y. Xu, C. Li, J. An, X. Ma, J. Yang, L. Luo, Y. Deng, J. S. Kim, Y. Sun, ‘Construction of a 980 nm laser-activated Pt(II) metallacycle nanosystem for efficient and safe photo-induced bacteria sterilization’ Sci. China. Chem. 2023, 66, 155. Read here
  • Y. Xu, Y. Zhang, J. Li, J. An, C. Li, S. Bai, A. Sharma, G. Deng, J. S. Kim, Y. Sun, ‘NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens’ Biomaterials 2020, 259, 120315. Read here
    • MORE VIEW
    • Y. Xu, C. Li, X. Ma, W. Tuo, L. Tu, X. Li, Y. Sun, P. J. Stang, Y. Sun, ‘Long wavelength–emissive Ru(II) metallacycle-based photosensitizer assisting in vivo bacterial diagnosis and antibacterial treatment’ Proc. Natl. Acad. Sci. USA 2022, 119, e2209904119. Read here
    • Y. Xu, C. Li, S. Lu, Z. Wang, S. Liu, X. Yu, X. Li, Y. Sun, ‘Construction of emissive ruthenium(II) metallacycle over 1000 nm wavelength for in vivo biomedical applications’ Nat. Commun. 2022, 13, 2009. Read here
    • Y. Xu, Y. Pang, L. Luo, A. Sharma, J. Yang, C. Li, S. Liu, J. Zhan, Y. Sun, ‘De Novo Designed Ru(II) Metallacycle as a Microenvironment-Adaptive Sonosensitizer and Sonocatalyst for Multidrug-Resistant Biofilms Eradication’ Angew. Chem. Int. Ed. 2024, 63, e202319966. Read here

Qihang Ding

Research interest

Fabrication of organic small molecule probes in the NIR-II

Contact
office
Asan sci. 238
E-mail
dingqihang at whu.edu.cn
Publications
  • Q. Li, Q. Ding, Y. Li, X. Zeng, Y. Liu, S. Lu, H. Zhou, X. Wang, J.Wu, X. Meng, Z. Denga and Y. Xiao ‘Novel small-molecule fluorophores for in vivo NIR-IIa and NIR-IIb imaging’ Chemical Communications. doi:10.1039/c9cc09865h
  • Y. Li, Y. Liu, Q. Li, X. Zeng, T. Tian, W.Zhou, Y. Cui, X. Wang, X. Cheng, Q. Ding, X. Wang, J. Wu, H. Deng, Y. Li, X. Meng, Z. Deng, X. Honga, and Y. Xiao ‘Novel NIR-II organic fluorophores for bioimaging beyond 1550 nm’ Chemical Science. doi:10.1039/c9sc06567a
  • H. Zhou, W. Yi, A. Li, B. Wang, Q. Ding, L. Xue, X. Zeng, Y. Feng, Q. Li, T. Wang, Y. Li, X. Cheng, L. Tang, Z. Deng, M. Wu, Y. Xiao, and X. Hong ‘Specific Small‐Molecule NIR‐II Fluorescence Imaging of Osteosarcoma and Lung Metastasis’ Advanced Healthcare Materials. doi:10.1002/adhm.201901224
    • MORE VIEW
    • J. Lin, Q. Li, X. Zeng, Z. Chen, Q. Ding, Y. Li, H. Zhou, X. Meng, D. Chen, Z. Deng, X. Hong and Y. Xiao ‘A novel small-molecule near-infrared II fluorescence probe for orthotopic osteosarcoma imaging’ SCIENCE CHINA Chemistry 63, 766 (2020); doi: 10.1007/s11426-019-9685-6

Kai Yu

Research interest

Brain-targeted nanomedicine, NIR-II bioimaging

Contact
office
Asan Sci. 337
E-mail
kaiyuwhu at whu.edu.cn
Publications
  • Y. Zhang†, S. Feng†, K. Yu†, Y. Gao, Z. Jian, Q. Chen*, L. Gu*, X. Xiong, ‘Nootkatone confers MAOB-dependent neuroprotection against ferroptotic injury via brain-targeted nanoparticle delivery in ischemic stroke’ J. Nanobiotechnol. 2026, 24, 619. Read here

  • K. Yu†, L. Fu†, Y. Chao†, X. Zeng†, Y. Zhang, Y. Chen, J. Gao, B. Lu, H. Zhu, L. Gu, X. Xiong*, Z. Hu*, X. Hong*, Y. Xiao*, ‘Deep Learning Enhanced Near Infrared-II Imaging and Image-Guided Small Interfering Ribonucleic Acid Therapy of Ischemic Stroke’ ACS Nano 2025, 19, 10323-10336. Read here

    • MORE VIEW
    • J. Gao†, K. Yu†, Q. Luo, M. Deng, X. Hou, W. Wang, X. Zeng, X. Xiong, Y. He, X. Hong*, Y. Xiao*, ‘Near-Infrared II Fluorescence Imaging and Image-Guided siRNA Therapy of Atherosclerosis’ J. Med. Chem. 2024, 67, 12428-12438. Read here

    • Z. Jian†, Y. Ye†, K. Yu†, W. Hu, H. Zhu, J. Wang, X. Xiong, C. Li*, L. Gu*, ‘Ratiometric Two-Photon Fluorescent Probe for Imaging Hydrogen Peroxide During Stroke-Induced Ferroptosis’ Sens. Actuators B Chem. 2024, 417, 136064. Read here

    • K. Yu†, Q. Tian†, S. Feng, Y. Zhang, Z. Cheng, M. Li, H. Zhu, J. He, M. Li*, X. Xiong*, ‘Integration Analysis of Cell Division Cycle-Associated Family Genes Revealed Potential Mechanisms of Gliomagenesis and Constructed an Artificial Intelligence-Driven Prognostic Signature’ Cell. Signal. 2024, 119, 111168. Read here

    • K. Yu†, Y. Ji†, M. Liu, F. Shen, X. Xiong, L. Gu, T. Lu, Y. Ye, S. Feng, J. He*, ‘High Expression of CKS2 Predicts Adverse Outcomes: A Potential Therapeutic Target for Glioma’ Front. Immunol. 2022, 13, 881453. Read here

    • K. Yu†, H. Yang, Q. L. Lv, L. C. Wang, Z. L. Tan, Z. Zhang, Y. L. Ji, Q. X. Lin, J. J. Chen, W. He, Z. Chen, X. L. Shen*, ‘Construction of a Competitive Endogenous RNA Network and Analysis of Potential Regulatory Axis Targets in Glioblastoma’ Cancer Cell Int. 2021, 21, 102. Read here

Xiao Fu

Research interest

Controllable Nanoparticles, Drug Delivery System, Theranostics

Contact
office
Asan Sci. 238
E-mail
fuxiao at sdfmu.edu.cn
Publications
  • M. Li, J. Liang, L. Ding, W. Dong, D. Zhang, D. Zhang, Y. Zhang, X. Fu*, ‘Stromal Reprogramming-Primed Nanofiber Enhances Immune Activation for Melanoma Suppression’, Chem. Eng. J., 2026, 533, 174721.
  • W. Ning, Y. Sun, M. Li, S Liu, F Yi, D. Liu, F Zhao*, G. Zhang*, X. Fu*, ‘A nanoplatform that induces dual-amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy’, BMEMat., 2026, e70083.
    • MORE VIEW
    • M. Li, X, Zhang; W. Li, Y. Zhang, B. Yuan, H. Tian, D. Zhang, Z. Liu, X. Fu*, ‘Copper-Based Metal-Polyphenol Network Encapsulated Mesoporous Silica for Targeted Cuproptosis Induction and Immunotherapy in Melanoma’, ACS AMI, 2026, 18, 21529.
    • Y. Geng, C. Meng, H. Zhang, C. Ma*, X. Fu*, H. Wu*, ‘A novel therapeutic approach to hemangiomas: Combining photothermal therapy and ferroptosis in a microneedle delivery system’, Mater. Today Bio., 2025, 32, 101748.
    • Y. Wang, Y. Sun, J. Song, D. Fa, Y. Qu, J. Li, X. Fu*, L. Ma*, ‘Injectable Nanocomposite Hydrogel with Antibacterial/Osteogenic Dual Functions for Synergistic Repair of Infectious Bone Defects in Hyperlipidemia Microenvironment’, Chem. Eng. J., 2025, 526, 170537.
    • M. Li , W. Dong , Y. Cui , J. Li, C. Yang, D. Zhang*, X. Fu*, ‘Engineered Biomimetic Vesicles Induce Cuproptosis and Disrupt Efferocytosis for Metastatic Adenoid Cystic Carcinoma Immunotherapy’, Mater. Today Bio., 2025, 102233.
    • M. Li, R. Li, B. Xu, X. Fu*, ‘Nanoparticle-Modified Nanofibers Induce Ferroptosis and Stimulate Antitumor Immunity for Melanoma Therapy’, Adv. Sci., 2025, e08753.
    • Y. Ma, M. Li, X. Fu, D. Li, C. Gao, Z. Li, Y. Zhang, Z. Gao, H. Geng, G. Li, S. Ni*, J. Cui*, ‘Engineering of Nanofibers Embedded with Targeted Nanoparticles Breaks Redox Levers for Glioblastoma Therapy’, Adv. Funct. Mater.<.i>, 2024, 2413518.
    • Y. Zhao, R. Song, Z. Zhang, H. Hu, W. Ning, X. Duan, J. Jiao,X. Fu*, G. Zhang*, ‘Hollow metal–organic framework-based, stimulator of interferon genes pathway-activating nanovaccines for tumor immunotherapy’, Nanoscale Adv., 2024, 6, 72-78.
    • X. Ma, W. Ning, Y. Geng, H. Shao, Y. Liu, F. Liu, D. Zhang, B. Chi, Y. Hou∗, X. Fu*, ‘An ECM-mimicking assembled gelatin/hyaluronic acid hydrogel with antibacterial and radical scavenging functions for accelerating open wound healing’, Biomed. Mater., 2024, 19, 015008.
    • Y. Geng, S. Huang, L. Ma, M. Li, E. Yang, Y. Li, D. Zhang*, X. Fu*, H. Wu*, ‘Propranolol-induced autophagic dysfunction combined with a targeted metal-organic framework as a novel strategy for improving antitumor therapeutic efffcacy’, Appl. Mater. Today, 2023, 33, 101886.
    • X. Fu, M. Li, J. Ju, H. Wu, Y. Geng, S. Jia, S. Li, S. Huang, ‘Nanoporous Silica Nanoparticles Coloaded with Cisplatin Prodrug and l -Buthionine Sulfoximine for Cancer Therapy’, ACS Appl. Nano Mater., 2023, 6, 2569–2576 .
    • X. Fu, Y. Zhang, G. Zhang, X. Li, S. Ni, J. Cui, ‘Targeted Delivery of Fenton Reaction Packages and Drugs for Cancer Theranostics’, Appl. Mater. Today, 2022, 26, 101353.
    • X. Fu, G. Zhang, Y. Zhang, H. Sun, S. Yang, S. Ni, J. Cui, ‘Co-Delivery of Anticancer Drugs and Cell Penetrating Peptides for Improved Cancer Therapy’, Chin. Chem. Letters, 2021, 32, 1559.
    • X. Fu, H. Sun, G. Zhang, K. Zhao, Y. Tian, Z. Gao, J. Cui, Q. Yu, ‘Targeted Poly(ethylene glycol) Nanoparticles for Photodynamic Therapy’, Colloid. Surface. A, 2020, 606, 125394.
    • X. Fu, L. Hosta-Rigau, R. Chandrawati, J. Cui, ‘Multi-Stimuli-Responsive Polymer Particles, Films, and Hydrogels for Drug Delivery’, Chem, 2018, 4, 2084.


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