MEMBERS

Next-generation
Molecular Theranostics Lab

Post Doctor

Ph.D Course

Master Course

Internship Course

Administration officer

Alumni

Post Doctor

HOME > MEMBERS > Post Doctor

원미애(Miae Won)

Research interest

Molecular biology

Contact
office
Asan Sci. 123A
E-mail
miaewon at korea.ac.kr
Publications
  • J. An, H. Hong, M. Won, H. Rha, Q. Ding, N. Kang, H. Kang, J. S. Kim, ‘Mechanical stimuli-driven cancer therapeutics’ Chem. Soc. Rev., 2023, DOI:10.1039/D2CS00546H.
  • X. Shi, M. Won, C. Tang, Q. Ding, A. Sharma, F. Wang, J. S. Kim, ‘RNA splicing based on reporter genes system: Detection, imaging and applications’ Coord. Chem. Rev., 477, 214929, 2023.
  • M. Park, K. Sunwoo, Y.-J. Kim, M. Won, Y. Xu, Z. Pu, M. Li, J. Y. Kim, J. H. Seo, J. S. Kim, ‘Cutting Off H​+ Leaks on Inner Mitochondrial Membrane: A Proton Modulation Approach to Selectively Eradicate Cancer Stem Cells’ J. Am. Chem. Soc. 2022 (in press).
    • MORE VIEW
    • S.-M. Jo, H. S. Kim, M. Won, C. Champanhac, J. S. Kim, F. R. Wurm, K. Landfester, ‘Dual-targeted Nanoreactors and Prodrugs: Hydrogen Peroxide triggers Oxidative Damages and Prodrug Activation for Synergistic Cancer Ablation’ Adv. Func. Mat. 2022, 220091.
    • S. Sen, M. Won, M. S. Levine, Y. Noh, A. C. Sedgwick, J. S. Kim, J. L. Sessler, J. F. rambula ‘Metal-based anticancer agents as immunogenic cell death inducers: the past, present, and future’ Chem. Soc. Rev. 2022, 51, 1212-1233.
    • H. Zhang, K. Li, L. Shi, X. Liu, M. Won, Y.-Z. Liu, Y. Choe, X.-Y. Liu, Y.-H. Liu, S.-Y. Chen, K.-K. Yu, J. S. Kim, X.-Q. Yu, ‘Discovery of Ultra-rapid/sensitive Lysosomal Fluorescence Lipophagy Process’ Angew. Chem. Int. Ed. 2022, e2021164439.
    • M. Won, J. H. Kim, M. S. Ji, J. S. Kim, ‘ROS activatable prodrug for ALDH overexpressed cancer stem cells’ Chem. Commun. 2022, 58, 72-75.
    • H. S. Jung, S. Koo, M. Won, S. An, H. Park, J. L. Sessler, J. Han, J. S. Kim, ‘Carbonic Anhydrase IX-targeted Chemodynamic & Photodynamic Cancer Stem Cell Therapy’ Nat. Commun., 2022 (in revision).
    • J. H. Kim, P. Verwilst, M. Won, J. Lee, J. L. Sessler, J. Han, J. S. Kim, ‘A small molecule strategy for targeting cancer stem cells in hypoxic microenvironments and preventing tumorigenesis’ J. Am. Chem. Soc., 2021, 143, 35, 14115–14124. (COVER)
    • S. Son, C. Zhang, M. Won, P. Jangili, M. Choi, J. Wu, J. S. Kim ‘Ultrasound activatable antiangiogenic sonosensitizer for VEGFR associated glioblastoma tumor models’ Aggregate, e972022, 2, 2021 (COVER).
    • S. Wang, W. X. Ren, J.-T. Hou, M. Won, J. An, Z. Chen, J. Shu, J. S. Kim, ‘Fluorescence imaging of pathophysiological microenvironments’ Chem. Soc. Rev., 50, 8887-8902, 2021.
    • W. Y. Kim, M. Won, S. Koo, X. Zhang, J. S. Kim ‘Mitochondrial H2Sn-Mediated Anti-Inflammatory Theranostics’ Nano-Micro Lett., 13, 168, 2021 (COVER).
    • S. Koo, M. Won, H. Li, W. Y. Kim, M. Li, C. Yan, A. Sharma, Z. Guo, W.-H. Zhu, J. L. Sessler, J. Y. Lee, J. S. Kim, ‘Harnessing α-L-fucosidase for in vivo cellular senescence imaging’ Chem. Sci., 12, 10054-10062, 2021.
    • J. Zhang, J. Kan, Y. Sun, M. Won, J. H. Kim, W. Zhang, J. Zhou, Z. Qian, J. S. Kim, ‘Nanoliposomal Ratiometric Fluorescent Probe toward ONOO– Flux’ ACS Appl. Bio. Mater., 4, 2080-2088, 2021. (Front cover)
    • M. Won, S. Koo, H. Li, J. L. Sessler, J. Y. Lee, A. Sharma, J. S. Kim ‘An Ethacrynic Acid-Brominated BODIPY Photosensitizer (EA-BPS) Construct Enhances the Lethality of Reactive Oxygen Species in Hypoxic Tumor-Targeted Photodynamic Therapy’ Angew. Chem. Int. Ed., 60, 3196-3204, 2021.
    • M. Won, M. Li, H. S. Kim, P. Liu, S. Koo, S. Son, J. H. Seo, J. S. Kim ‘Visible to mid IR: A library of multispectral diagnostic imaging’ Coord. Chem. Rev., 426, 213608, 2021.
    • J. Zhou, P. Jangili, S. Son, M. S. Ji, M. Won, J. S. Kim, ‘Fluorescent Diagnostic Probes in Neurodegenerative Diseases’ Adv. Mater., 32, 2001945, 2020 (COVER).
    • J. Han, M. Won, J. H. Kim, E. Jung, J. Paramesh, K. Min, J. S. Kim, ‘Cancer Stem Cell-targeted Bio sensing & Chemotherapeutic Perspective’ Chem. Soc. Rev., 49, 7856-7878, 2020.
    • C. Liu, H. S. Kim, M. Won, E. Jung, J. S. Kim, ‘Navigating 2D Monoelemental Materials (Xenes) for Cancer Nanomedicine’ Matter (Cell Press), 3, 12-13, 2020.
    • K. Sunwoo, M. Won, K-P. Ko, S-G. Chi, P. Verwilst, J. S. Kim, ‘Mitochondrial relocation of a common synthetic antibiotic is key to non-genotoxic cancer therapy’ Chem (Cell Press), 6, 1408-1419, 2020.
    • J. H. Joo, M. Won, K. Park, D.-S. Shin, J. S. Kim, M. H. Lee, ‘A dicyanocoumarin-fused quinolinium based probe for NAD(P)H and its use for detecting glycolysis and hypoxia in living cells and tumor spheroids’ Sens. Actuators B: Chem., 320, 128360, 2020.
    • P. Liu, W. Fu, P. Verwilst, M. Won, J. Shin, Z. Cai, B. Tong, J. Shi, Y. Dong, J. S. Kim, ‘MDM2-Associated Clusterization-Triggered Emission and Apoptosis Induction Effectuated by a Theranostic Spiropolymer’ Angew. Chem. Int. Ed., 59, 8435-8439, 2020.
    • S. Y. Park, M. Won, J. S. Kim, M. H. Lee, ‘Ratiometric fluorescent probe for monitoring tyrosinase activity in melanosomes of melanoma cancer cells’ Sens. Actuators B: Chem., 319, 128306, 2020.
    • W. Y. Kim, M. Won, A. Salimi, A. Sharma, J. Lim, S-H. Kwon, J-Y. Jeon, J. Y. Lee, J. S. Kim, ‘Monoamine Oxidase-A Targeting Two Photon Probe for Prostate Tumor and Metastasis Imaging’ Chem. Commum., 13267, 55, 2019.
    • A. Sharma, M-G. Lee, M. Won, S. Koo, J. F. Arambula, J. L. Sessler, S-G. Chi, J. S. Kim, ‘Targeting Heterogenous Tumors Using a Multifunctional Molecular Prodrug’ J. Am. Chem. Soc., 15611-15618, 141, 2019. (Front Cover)
    • S. Koo, K. N. Bobba, H. S. Park, M. Y. Cho, M. Won, N. Valusamy, K. S. Hong, S. Bhuniya, J. S. Kim, ‘Molecular Theranostic Agent with Programmed Activation for Hypoxic Tumor’ ACS Appl. Bio Mater., 4648-4655, 2, 2019.
    • Y. Wang, M. Qiu, M. Won, E. Jung, T. Fan, N. Xie, S-G. Chi, H. Zhang, J. S. Kim, ‘Emerging 2D material-based nanocarrier for cancer therapy beyond graphene’ Coord. Chem. Rev., 213041, 400, 2019.
    • M. Won, Y. Luo, D.H. Lee, E. Shin, D.S. Suh, T.H. Kim, H. Jin, J. Bae, ‘BAX is an essential key mediator of AP5M1-induced apoptosis in cervical carcinoma cells’ Biochem. Biophys. Res. Commun., 368−373, 15, 2019.
    • P. Jangili, M. Won, S. J. Kim, J. Chun, I. Shim, C. Kang, W. X. Ren, J. S. Kim, ‘Binary drug reinforced first small molecule-based prodrug for synergistic anti-cancer effect’ ACS Appl. Bio Mater., 3532−3539, 2, 2019.
    • C. Duan, M. Won, P. Verwilst, J. Xu, H. S. Kim, L. Zeng, J. S. Kim, ‘In vivo imaging of endogenously produced HClO in zebrafish and mice using a bright, photostable ratiometric fluorescent probe’ Anal. Chem., 4172−4178, 91, 2019.
    • N. Y. Lim, J. Ahn, M. Won, W. Choi, J. S. Kim, J. H. Jung, ‘Novel Cyanostilbene-Based Fluorescent Probe for Hydroxyl Radicals and Its Two-Photon Bioimaging in Living Cells’ ACS Appl. Bio Mater., 936-642, 2, 2019.
    • S. Son, M. Won, O. Green, N. Hananya, A. Sharma, Y. Jeon, J. H. Kwak, J. L. Sessler, D. Shabat, J. S. Kim, ‘Chemiluminescent Probe for the In Vitro and In Vivo Imaging of Cancers Over-expressing NQO1’ Angew. Chem. Int. Ed., 1739-1743, 58, 2019.
    • S. Y. Park, M. Won, C. Kang, J. S. Kim, M. H. Lee, ‘A coumarin-naphthalimide hybrid as a ratiometric fluorescent probe for hNQO1’ Dyes & Pigm., 341-345, 164, 2019.
    • N. H. Kim, M. Won, J. S. Kim, Y. Huh, D. Kim, ‘A Highly Sensitive and Fast Responsive Fluorescent Probe for Detection of Gold(III) Ions based on the AIEgen Disaggregation’ Dyes & Pigm. 647-653, 160, 2019.
    • M. Qiu, W. Ren, T. Jung, M. Won, G. Y. Park, D. K. Sang, L.-P. Liu, H. Zhang, J. S. Kim, ‘Omnipotent Phosphorene: Next Generation Two-Dimensional Nanoplatform for Multidisciplinary Biomedical Applications’ Chem. Soc. Rev., 5588-5601, 47, 2018.
    • S. A. Yoon, W. Kim, A. Sharma, P. Verwilst, M. Won, M. H. Lee, ‘A Fluorescent Cy7-Mercaptopyridine for the Selective Detection of Glutathione over Homocysteine and Cysteine’ Sensors, 2897-2908, 18, 2018.
    • Y. Zhou, M. Maiti, A. Sharma, M. Won, L. Yu, L. X. Miao, J. Shin, A. Podder, K.N. Bobba, J. Han, S. Bhuniya, J.S. Kim, ‘Azo-based small molecular hypoxia responsive theranostic for tumor-specific imaging and therapy’ J. Control. Release, 14-22, 28, 2018.
    • A. Podder, M. Won, S. Kim, P. Verwilst, M. Maiti, Z. Yang, J. Qu, S. Bhuniya, J. S. Kim, ‘A two-photon fluorescent probe records the intracellular pH through ‘OR’ logic operation via internal calibration’ Sens. Act. B, 195-204, 268, 2018.
    • A. Sharma, M.-G. Lee, H. Shi, M. Won, J. F. Arambula, J. L. Sessler, J. Y. Lee, S.-G. Chi, J. S. Kim, ‘Overcoming Drug Resistance by Targeting Cancer Bioenergetics with an Activatable Prodrug’ Chem (Cell Press), 2370-2383, 4, 2018.
    • H. S. Kim., T. Park, W. X. Ren, J.-Y Lim, M. Won, J. S. Heo, S. G. Lee, and J. S. Kim ‘COX-2 targeting indomethacin conjugated fluorescent probe’ Dyes & Pigm., 261-266, 150, 2018.
    • K. N. Bobba, M. Won, I. Shim, N. Velusamy, Z. Yang, Junle Qu, J. S. Kim, S. Bhuniya, ‘BODIPY based Two Photon Fluorescent Probe Validates Tyrosinase Activity in Live Cells’ Chem. Commun., 11213-11216, 53, 2017.
    • H. Jin, M. Won, E. Shin, H. M. Kim, K. Lee K, J. Bae, ‘EGR2 is a gonadotropin-induced survival factor that controls the expression of IER3 in ovarian granulosa cells’ Biochem. Biophys. Res. Commun., 877-882, 482(4), 2017.
    • H. Jin, M. Won, S.E. Park, S. Lee, M. Park, J. Bae, ‘FOXL2 Is an Essential Activator of SF-1-Induced Transcriptional Regulation of Anti-Müllerian Hormone in Human Granulosa Cells’ PLoS One, e0159112, 11, 2016.
    • S. M. Ryou, J. H. Yeom, H. J. Kang, M. Won, J. S. Kim, B. Lee, M. J. Seong, N. C. Ha, J. Bae, K. Lee, ‘Gold nanoparticle-DNA aptamer composites as a universal carrier for in vivo delivery of biologically functional proteins’ J. Control. Release, 287-380, 196, 2014.
    • J. H. Yeom, S. M. Ryou, M. Won, M. Park, J. Bae, K. Lee, ‘Inhibition of Xenograft tumor growth by gold nanoparticle-DNA oligonucleotide conjugates-assisted delivery of BAX mRNA’ PLoS One, e75369, 8, 2013.
    • J. Bae, M. Won, D. Y. Kim, J. H. Kim, Y. M. Kim, Y. T. Kim, J. H. Nam, D. S. Suh, ‘Identification of differentially expressed microRNAs in endometrial cancer cells after progesterone treatment’ Int. J. Gynecol. Cancer, 561-565, 22, 2012.
    • S. Lee, T. H. Kim, M. Won, J. J. Ko, J. Rho, K. Lee, J. Bae, ‘Absence of a FOXL2 mutation (402C→G) in the blood of adult-type granulosa cell tumor patients possessing the FOXL2 mutation’ Int. J. Gynecol. Cancer, 1341-1343, 20, 2010.
    • D. H. Choi, W. S. Lee, M. Won, M. Park, H. O. Park, E. Kim, K. A. Lee, J. Bae, ‘The apolipoprotein A-I level is downregulated in the granulosa cells of patients with polycystic ovary syndrome and affects steroidogenesis’ J. Proteome Res., 4329-4364, 9, 2010.
    • M. Park, E. Shin, M. Won, J. H. Kim, H. Go, H.L. Kim, J. J. Ko, K. Lee, J. Bae,, ‘FOXL2 interacts with steroidogenic factor-1 (SF-1) and represses SF-1-induced CYP17 transcription in granulosa cells’ Mol. Endocrinol., 1024-1059, 24, 2010.
    • S. Yoon, H. J. Ha, Y. H. Kim, M. Won, M. Park, J. J. Ko, K. Lee, J. Bae J, ‘IEX-1-induced cell death requires BIM and is modulated by MCL-1’ Biochem. Biophys. Res. Commun., 400-403, 382, 2009.
    • J. H. Kim, S. Yoon, M. Won, S. H. Sim, J. J. Ko, S. Han, K. A. Lee, K. Lee, J. Bae J, ‘HIP1R interacts with a member of Bcl-2 family, BCL2L10, and induces BAK-dependent cell death’ Cell Physiol. Biochem., 43-52, 23, 2009.
    • J. Han, M. Park, J. H. Kim, A. Kim, M. Won, D. R. Lee, J. J. Ko, H. Yoon, S. H. Sim, K. Lee, J. Bae, ‘Increased expression of the testicular estrogen receptor alpha in adult mice exposed to low doses of methiocarb’ J. Appl. Toxicol., 446-496, 29, 2009.
    • E. Shin, H. Go, J. H. Yeom, M. Won, J. Bae, S. H. Han, K. Han, Y. Lee Y, N. C. Ha, C. J. Moore, B. Sohlberg, S. N. Cohen, K. Lee, ‘Identification of amino acid residues in the catalytic domain of RNase E essential for survival of Escherichia coli: functional analysis of DNase I subdomain’ Genetics, 1871-1879, 179, 2008.
    • M. Won, S. Lee, S. Kim, S. Yoon, J. J. Ko, K. Lee, J. Bae, ‘Apoptosis of the mitochondria protein p32 (gc1qbp) in human ovarian cancer cells’ Korean Journal of Obestetrics & Gynecology, 858-865, 51, 2008.
    • Y. Kang, D. C. Lee, J. Han, S. Yoon, M. Won, J. H. Yeom, M, J. Seong, J. J. Ko, K. A. Lee, K. Lee, J. Bae, ‘NM23-H2 involves in negative regulation of Diva and Bcl2L10 in apoptosis signaling’ Biochem. Biophys. Res. Commun., 76-82, 359, 2007.

Mingle Li

Research interest

Drug Delivery System & Bioimaging & PDT/PTT/SDT

Contact
office
Asan Sci. 337
E-mail
limingle611 at 163.com
Publications
  • Han, H-H.; Wang, H-M.; Jangjili, P.; Li, M.; Wu, L.; Zang, Y.; Sedgwick, A. C.; Li, J.; He, X-P.; James, T. D.; Kim, J. S. The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy. Chem. Soc. Rev. 2023, in press.
  • Park, M.; Sunwoo, K.; Kim, Y-J.; Won, M.; Xu, Y.; Kim, J.; Pu, Z.; Li, M.*; Kim, J. Y.*; Seo, J. H.*; Kim, J. S.* Cutting Off H+ Leaks on Inner Mitochondrial Membrane: A Proton Modulation Approach to Selectively Eradicate Cancer Stem Cells. J. Am. Chem. Soc. 2023, in press.
  • Zheng, L.*; Zhang, H.; Won, M.; Kim, E.; Li, M.*; Kim, J. S.* Codoping g-C3N4 with boron and graphene quantum dots: enhancement of charge transfer for ultrasensitive and selective photoelectrochemical detection of dopamine. Biosens. Bioelectron. 2023, 224, 115050.
    • MORE VIEW
    • Xiong, H.; Xu, Y.; Kim, B.; Rha, H.; Zhang, B.; Li, M.*; Yang, G-F.*; Kim, J. S.* Photo-Controllable Biochemistry: Exploiting Photocages in the Phototherapeutic Window. Chem 2023, 9, 29-64.
    • Li, M.; Kim, J.; Xu, Y.; Kim, J. S. An acid-activatable nanosensitizer library realizes tunable pyroptosis activation in tumors, Matter. 2023, 6,7-29.
    • Li, M.; Xu, Y.; Rhee, H-W; Kim, J. S. Deep-red-light photocatalytic protein proximity labelling, Chem. 2022, 8, 3159-3174.
    • Li, M.; Xu, Y.; Peng, X.; Kim, J. S. From Low to No O2-Dependent Hypoxia Photodynamic Therapy (hPDT): A New Perspective. Acc. Chem. Res. 2022, 55, 3253-3264.
    • Son, S.; Kim, J.; Kim, J.; Kim, B.; Lee, J.; Kim, Y.; Li, M.*; Kang, H.*; Kim, J. S.* Cancer therapeutics based on diverse energy sources. Chem. Soc. Rev. 2022, 51, 8201-8215.
    • Li, M.; Xu, Y., Pu, Z., Xiong, T., Huang, H., Long, S., Son, S., Yu, L., Singh, N., Tong, Y., Sessler, J. L., Peng, X., Kim, J. S., Photoredox catalysis may be a general mechanism of photodynamic therapy. Proc. Natl. Acad. Sci. U.S.A. 2022, 119, e2210504119.
    • Li, M.; Gebremedhin, K. H.; Ma, D.; Pu, Z.; Xiong, T.; Xu, Y.; Kim, J. S.; Peng, X., Conditionally Activatable Photoredox Catalysis in Living Systems. J. Am. Chem. Soc. 2022, 144, 163-173.
    • Yu, L.; Xu, Y.; Pu, Z.; Kang, H.; Li, M.*; Sessler, J. L.*; Kim, J. S.*, Photocatalytic Superoxide Radical Generator that Induces Pyroptosis in Cancer Cells. J. Am. Chem. Soc. 2022, 144, 11326-11337.
    • Xu, Y.; Xiong, H.; Zhang, B.; Lee, I.; Xie, J.; Li, M.*; Zhang, H.*; Kim, J. S.*, Photodynamic Alzheimer’s disease therapy: From molecular catalysis to photo-nanomedicine. Coordin. Chem. Rev. 2022, 470, 214726.
    • Xu, Y.; Wang, Y.; An, J.; Sedgwick, A. C.; Li, M.; Xie, J.; Hu, W.; Kang, J.; Sen, S.; Steinbrueck, A., 2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy. Bioact. Mater. 2022, 14, 76-85.
    • Koo, S.; Lee, M. G.; Sharma, A.; Li, M.; Zhang, X.; Pu, K.; Chi, S. G.; Kim, J. S., Harnessing GLUT1‐Targeted Pro‐oxidant Ascorbate for Synergistic Phototherapeutics. Angew. Chem. Int. Ed. 2022, 61, e202110832.
    • Xiong, T.; Chen, Y.; Li, M.; Long, S.; Du, J.; Fan, J.; Peng, X., A benzophenoxazine-dyad as cancer indicator using for fluorescence-guided phototherapy. Sens. Actuators B Chem. 2022, 352, 130990.
    • Ma, D.; Bian, H.; Long, S.; Zhou, P.; Tian, R.; Wu, Y.; Ge, H.; Li, M.; Du, J.; Fan, J., Se-sensitized NIR hot band absorption photosensitizer for anti-Stokes excitation deep photodynamic therapy. Sci. China Chem. 2022, 65 (3), 563-573.
    • H. Chu, L. Yang, L. Yu, J. Kim, J. Zhou*, M. Li*, J. S. Kim*, ‘Fluorescent probes in public health and public safety’ Coord. Chem. Rev. 214208, 449, 2021.
    • S. Koo, M. Won, H. Li, W. Y. Kim, M. Li, C. Yan, A. Sharma, Z. Guo, W.-H. Zhu, J. L. Sessler, J. Y. Lee, J. S. Kim, ‘Harnessing α-L-fucosidase for in vivo cellular senescence imaging’ Chem. Sci., 12, 10054-10062, 2021.
    • M. Won, M. Li, H. S. Kim, P. Liu, S. Koo, S. Son, J. H. Seo, J. S. Kim ‘Visible to mid IR: A library of multispectral diagnostic imaging’ Coord. Chem. Rev. 213608, 426, 2021.
    • Y. Zou, M. Li, T. Xiong, X. Zhao, J. Du, J. Fan, X. Peng. ‘A Single Molecule Drug Targeting Photosensitizer for Enhanced Breast Cancer Photothermal Therapy’ Small, DOI:10.1002/smll.201907677, 2020.
    • M. Li, Y. Shao, J.H. Kim, Z. Pu, X. Zhao, H. Huang, T. Xiong, Y. Kang, G.-Z. Li, K. Shao, J. Fan, J. W. Foley, J. S. Kim, X. Peng. ‘Unimolecular Photodynamic O2-Economizer To Overcome Hypoxia Resistance in Phototherapeutics’ J. Am. Chem. Soc., 5380-5388, 142, 2020.
    • H. Huang, D. Huang, M. Li, Q. Yao, R. Tian, S. Long, J. Fan, X. Peng. ‘NIR aza-pentamethine dyes as photosensitizers for photodynamic therapy’ Dyes and Pigments. 108284, 177, 2020
    • C. Shi, M. Li, Z. Zhang, Q. Yao, K. Shao, F. Xu, N. Xu, H. Li, J. Fan, W. Sun, J. Du, S. Long, J. Wang, X. Peng. ‘Catalase-based liposomal for reversing immunosuppressive tumor microenvironment and enhanced cancer chemo-photodynamic therapy’ Biomaterials. 119755, 233, 2020.
    • X. Zhao, S. Long. M. Li, J. Cao, Y. Li, L. Guo, W. Sun, J. Du, J. Fan, X. Peng. ‘Oxygen-Dependent Regulation of Excited-State Deactivation Process of Rational Photosensitizer for Smart Phototherapy’ J. Am. Chem. Soc.1510-1517, 142, 2020.
    • T. Xiong, M. Li, X. Zhao, Y. Zou, J. Du, J. Fan, X. Peng. ‘Functional two-photon cationic targeted photosensitizers for deep-seated tumor imaging and therapy’ Sensor B. Chem. 127310, 304, 2020.
    • R. Tian, W. Sun, M. Li, S. Long, M. Li, J. Fan, L. Guo, X. Peng. ‘Development of A Novel Anti-tumor Theranostic Platform: Near-Infrared Molecular Upconversion Sensitizer for Deep-seated Cancer Photodynamic Therapy’ Chem. Sci. 10106-10112, 10, 2019.
    • B. Gurram, M. Li, M. Li, Kalayou H. Gebremedhin, W. Sun, J. Wang, X. Peng. ‘NIR excited superoxide radical procreators to eradicate the tumor by targeting lyso-membrane’ J. Mater. Chem. B. 4440-4450, 7, 2019.
    • Kalayou H. Gebremedhin, M. Li, F. Gao, B. Gurram, J. Fan, J. Wang, Y. Li. X. Peng. ‘Benzo[a]phenoselenazine-based NIR photosensitizer for tumor-targeting photodynamic therapy via lysosomal-disruption pathway’ Dye Pigm. 107617, 170, 2019.
    • Y. Kang, W. Sun, S. Li, M. Li, J. Fan, X. Peng. ‘Oligo Hyaluronan‐Coated Silica/Hydroxyapatite Degradable Nanoparticles for Targeted Cancer Treatment’ Adv. Sci. 1900716, 13, 2019.
    • M. Li, T. Xiong, J. Du, R. Tian, M. Xiao, L. Guo, S. Long, J. Fan, W. Sun, K. Shao, X. Song, J. W. Foley, X. Peng. ‘Superoxide Radical Photogenerator with Amplification Effect: Surmounting the Achilles’ Heels of Photodynamic Oncotherapy’ J. Am. Chem. Soc. 2695-2702, 214, 2019.
    • M. Li, S. Long, Y. Kang, L. Guo, J. Wang, J. Fan, J. Du, X. Peng. ‘De Novo Design of Phototheranostic Sensitizers Based on Structure-Inherent Targeting for Enhanced Cancer Ablation’ J. Am. Chem. Soc. 15820-15826, 140, 2018.
    • M. Li, J. Xia, R. Tian, J. Wang, J. Fan, J. Du, S. Long, X. Song, J. W. Foley, X. Peng. ‘NIR Light-Initiated Molecular Superoxide Radical Generator: Rejuvenating Photodynamic Therapy against Hypoxic Tumors’ J. Am. Chem. Soc. 14851-14859, 140, 2018.
    • Y. Kang, W. Sun, J. Fan, Z. Wei, S. Wang, M. Li, Z. Zhang, Y. Xie, J. Du, X. Peng. ‘Ratiometric Real-Time Monitoring of Hydroxyapatite-Doxorubicin Nanotheranostic Agents for On-Demand Tumor Targeted Chemotherapy’ Mater. Chem. Front., 1791-1798, 2, 2018.
    • X. Zhao, M. Li, W. Sun, J. Fan, X. Peng. ‘An Estrogen Receptor Targeted Ruthenium Complex as a Two-Photon Photodynamic Therapy Agent for Breast Cancer Cells’ Chem. Commun., 7038-7041, 54, 2018.
    • H. Huang, S. Long, M. Li, F. Gao, J. Du, J, Fan, X. Peng. ‘Bromo-pentamethine as mitochondria-targeted photosensitizers for cancer cell apoptosis with high efficiency’ Dye Pigm. 633-638, 149, 2018.
    • Y. Bian, M. Li, J. Fan, J. Du, S. Long, X. Peng. ‘A proton-activatable aminated-chrysophanol sensitizer for photodynamic therapy’ Dye Pigm. 476-483, 147, 2017.
    • H. Huang, S. Long, M. Li, J. Du, J. Fan, X. Peng. ‘Pentamethine cyanine located in mitochondria: relationship between photostability and excited state lifetime’ Scientia Sinica Chimica, 1035-1043, 47, 2017.
    • M. Li, R. Tian, J. Fan, J. Du, S. Long, X. Peng. ‘A lysosome-targeted BODIPY as potential NIR photosensitizer for photodynamic therapy’ Dye Pigm. 99-105, 147, 2017.
    • M. Li, X. Peng. ‘Research Progress on the Phthalocyanine Based Targeting Photosensitizers in Photodynamic Therapy’ Acta Chim Sinica. 959-968, 74, 2016.

Nem Singh

Research interest

Polymeric Nanoparticles for Drug Delivery and Photodynamic Therapy

Contact
office
Asan Sci. 346
E-mail
nsingh at korea.ac.kr
Publications
  • N. Singh, J. Kim, J. Kim, K. Lee, Z. Zunbul, I. Lee, E. Kim, S. G. Chi, J. S. Kim*, ‘Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications’ Bioactive Materials, 2023, 21, 358-380.
  • M. Li, Y. Xu, Z. Pu, T. Xiong, H. Huang, S. Long, S. Son, L. Yu, N. Singh, Y. Tong, J. L. Sessler, X. Peng, J. S. Kim*, ‘Photoredox catalysis may be a general mechanism in photodynamic therapy’ Proc. Natl. Acad. Sci. U.S.A, 2022, 34, 119, e2210504119.
  • J. H. Kim, D. W. Kang, H. Yun, M. Kang, N. Singh*, J. S Kim*, C. S. Hong* ‘Post-synthetic modifications in porous organic polymers for biomedical and related applications’ Chem. Soc. Rev. 2022, 51, 43-56.
    • MORE VIEW
    • P. Jangili, N. Singh, I. Kim, Z. Zunbul, J. S. Kim*, ‘Chemo-and Bio-Sensors for Copper Ions Molecular Bio-Sensors and the Role of Metal Ions’ 2022, 181-210.
    • J. H. Kim, H. Yun, D. W. Kang, J. Shin, M. Kang, N. Singh, J.-E. Jeong, C. S. Hong*, J. S. Kim*, ‘Isomeric sp2-Carbon Porous Organic Polymer-mediated Photo- and Sono-catalytic Detoxification of Sulfur Mustard under Ambient Conditions’ Matter 2021, 4, 3774–3785.
    • N. Singh, S. Son, J. An, I. Kim, M. Choi, N. Kong, W. Tao*, J. S. Kim*, ‘Nanoscale porous organic polymers for drug delivery and advanced cancer theranostics’ Chem. Soc. Rev., 2021, 50, 12883-12896.
    • N. Singh, D. Yadav, S. V. Mulay, J. Y. Kim, N. J. Park, J. O. Baeg* ‘Band Gap Engineering in Solvochromic 2D Covalent Organic Framework Photocatalysts for Visible Light-Driven Enhanced Solar Fuel Production from Carbon Dioxide’ACS Applied Materials & Interfaces, 2021, 13, 14122
    • L. Huang, S. Zhao, J. Wu, L. Yu, N. Singh, K. Yang, M. Lan*, P. Wang*, J. S. Kim*, ‘Photodynamic therapy for hypoxic tumors: Advances and perspectives’ Coordination Chemistry Reviews, 2021, 438, 213888 (DOI: 10.1016/j.ccr.2021.213888)
    • J. Singh, D. W. Park, D. H. Kim, N. Singh, S. C. Kang, K. W. Chi, ‘Coordination-Driven Self-Assembly of Triazole-Based Apoptosis-Inducible Metallomacrocycles’ ACS omega, 10810-10817, 4, 2019.
    • D. Yadav, N. Singh, T. W. Kim, J. Y. Kim, N. J. Park, J. O. Baeg, ‘Highly regioselective and sustainable solar click reaction: a new post-synthetic modified triazole organic polymer as a recyclable photocatalyst for regioselective azide–alkyne’ Green Chemistry, 2677-2685, 21, 2019
    • H. S. Song, Y. H. Song, N. Singh, H. Kim, H. Jeon, I. Kim, S. C. Kang, K. W. Chi ‘New Self-assembled Supramolecular Bowls as Potent Anticancer Agents for Human Hepatocellular Carcinoma Scientific reports’ 1-13, 9, 2019.
    • J. Singh, D. H. Kim, E. H. Kim, N. Singh, H. Kim, R. Hadiputra, J .Jung, K. W. Chi, ‘Selective and quantitative synthesis of a linear [3] catenane by two component coordination-driven self-assembly\' Chem. Commun., 55, 6866-6869, 4, 2019.
    • N. Singh, S. C. Kang, K. W. Chi, CHAPTER 9: Applications of Self-assembled Metallomacrocycles I: Biological Applications; Metallomacrocycles: From Structures to Applications, 226-250, 2018.
    • D. H. Kim, N. Singh, J. Oh, E. H. Kim, J. Jung, H. Kim, K. W. Chi, ‘Coordination‐Driven Self‐Assembly of the Molecular Knot Comprising Sixteen Crossings’ Angew. Chem. Int. Ed., 5669-5673, 57, 2018.
    • N. Singh, J. Singh, D. Kim, D. H. Kim, E. H. Kim, M. S. Lah, K. W. Chi, ‘Coordination-Driven Self-Assembly of Heterotrimetallic Barrel and Bimetallic Cages Using a Cobalt Sandwich-Based Tetratopic Donor’ Inorg. chem., 3521–3528, 57, 2018.
    • J. H. Jo, N. Singh, D. Kim, S. M. Cho, A. Mishra, H. Kim, S. C. Kang, K. W. Chi, ‘Coordination-Driven Self-Assembly Using Ditopic Pyridyl–Pyrazolyl Donor and p-Cymene Ru(II) Acceptors: [2]Catenane Synthesis and Anticancer Activities’ Inorg. Chem., 8430-8438, 56, 2017.
    • N. Singh, D. Kim, D. H. Kim, E. H. Kim, H. Kim, M. S. Lah, K. W. Chi, ‘Selective synthesis of iridium (III)-derived molecular Borromean rings,[2] catenane and ring-in-ring macrocycles via coordination-driven self-assembly\' Dalton Trans.’ 571-577, 46, 2017.
    • N. Singh, S. Jang, J. H. Jo, D. H. Kim, D. W. Park, I. H. Kim, H. Kim, S. C. Kang, ‘Coordination‐driven self‐assembly and anticancer potency studies of Ruthenium–Cobalt‐Based heterometallic rectangles’ Chem. Eur. J., 16157., 22, 2016.
    • T. Kim, N. Singh, J. Oh, E. H. Kim, J. Jung, H. Kim, K. W. Chi ‘Selective synthesis of molecular Borromean rings: engineering of supramolecular topology via coordination-driven self-assembly\' 8368-8371, 138, 2016.
    • Y. H. Song, N. Singh, J. Jung, H. Kim, E. H. Kim, H. .K Cheong, Y. Kim, K. W. Chi, ‘Template‐Free Synthesis of a Molecular Solomon Link by Two‐Component Self‐Assembly’ Angew. Chem. Int. Ed., 2007-2011, 55, 2016.
    • D. Kumar, M. Deb, J. Singh, N. Singh, K. Keshav, A. J. Elias, ‘Chemistry of the highly stable hindered cobalt sandwich compound (η5-Cp)Co(η4-C4Ph4) and its derivatives’ Coord. Chem. Rev., 115-170, 306, 2016.
    • H. W. Lee, P. Elumalai, N. Singh, H. Kim, S. U. Lee, K. W. Chi, ‘Selective synthesis of ruthenium (II) metalla [2] catenane via solvent and guest-dependent self-assembly\' J. Am. Chem. Soc., 4674-4677, 137, 2015.
    • I. Kim, Y. H. Song, N. Singh, Y. J. Jeong, J. E. Kwon, H. Kim, Y. M. Cho, S. C. Kang, K. W. Chi, ‘Anticancer activities of self-assembled molecular bowls containing a phenanthrene-based donor and Ru (II) acceptors’ International journal of nanomedicine, 143, 10, 2015.
    • N. Singh, J. H. Jo, Y. H. Song, H. Kim, D. Kim, M. S. Lah, K. W. Chi, ‘Coordination-driven self-assembly of an iridium-cornered prismatic cage and encapsulation of three heteroguests in its large cavity’ Chem. Commum., 4492-4495, 51, 2015.
    • D. Kumar, N. Singh, A. J. Elias, P. Malik, C. W. Allen, ‘Reactions of Alkyne-and Butadiyne-Derived Fluorinated Cyclophosphazenes with Diiron and Dimolybdenum Carbonyls’ Inorg. Chem., 10674-10684, 53, 2014.
    • J. Singh, D. Kumar, N. Singh, A. J. Elias, ‘New Chiral Palladacycles from an Unprecedented Cyclopalladation of Cyclobutadiene-Bound Phenyl Groups of Cobalt Sandwich Compounds’ Organometallics, 1044-1052, 33, 2014.
    • D. Kumar, N. Singh, K. Keshav, A. J. Elias, ‘Synthesis and structural characterization of the first examples of butadiynyl derived cyclic fluorinated phosphazenes’ J. Fluor. Chem., 48-56, 153, 2013.
    • M. Ganesan, R. V. Salunke, N. Singh, N. G. Ramesh, ‘Protecting group directed diversity during Mitsunobu cyclization of a carbohydrate derived diamino triol. Synthesis of novel bridged bicyclic and six-membered iminocyclitols’ Organic & biomolecular chemistry 11, 599-611, 17, 2013.
    • N. Singh, B. P. R. Metla, A. J. Elias, ‘Synthesis and reactions of new 1, 2-and 1, 3-cyclopentadienyl disubstituted cobalt sandwich compounds (η5-C5H3R2) Co (η4-C4Ph4)(RCH2OH, CHO, CCH, CH2N3, CH2NH2, CH2OAc, CHNPh)’ J. Organomet. Chem., 99-107, 717, 2012.
    • P. Mandapati, N. Singh, D. Kumar, A. J. Elias, ‘Synthesis and characterization of difunctionalized derivatives of the cyclobutadiene linked dimeric cobalt sandwich compound [(η5-Cp) Co (η4-C4Ph3)]2’ J. Organomet. Chem., 208-215, 716, 2012.
    • N. Singh, A. J. Elias, ‘Cyclopentadienyl 1,2- and 1,3-Disubstituted Cobalt Sandwich Compounds {η5-[MeOC(O)]2C5H3} Co(η4-C4Ph4): Precursors for Sterically Hindered bidentate chiral and achiral ligands’ Organometallics 2059-2065, 31, 2012.
    • N. Singh, A. J. Elias, ‘Identification and characterization of intermediates in the formation of the cyclobutadiene linked dimeric cobalt sandwich compound [(-RCp)Co(-C4Ph3)]2’ J. Chem. Sci., 853-860, 123, 2011.
    • D. Kumar, N. Singh, K. Keshav, A. J. Elias, Ring-closing metathesis reactions of terminal alkene-derived cyclic phosphazenes Inorg. Chem., 250-260, 50, 2011.
    • N. Singh, A. J. Elias, ‘Palladacycles of novel bisoxazoline chelating ligands based on the dimeric cyclobutadiene linked cobalt sandwich compound [(η5-Cp) Co (η4-C4Ph3)]2’ Dalton Trans., 4882-4891, 40, 2011.
    • R. N. Ram, N. Kumar, N. Singh, ‘Synthesis of Chlorinated Bicyclic C-Fused Tetrahydrofuro[3,2-c]azetidin-2-ones\' J. Org. Chem. 7408-7411, 75, 2010.
    • K. Keshav, N. Singh, A. J. Elias, ‘Synthesis and reactions of ethynylferrocene-derived fluoro-and chlorocyclotriphosphazenes’ Inorg. Chem., 5753-5765, 49, 2010.
    • R. Jana, M. S. Kumar, N. Singh, A. J. Elias, ‘Synthesis, reactivity and structural studies of (η5-methylcyclopentadienyl)(η4-tetraphenylcyclobutadiene) cobalt and its derivatives’ J. Organomet. Chem., 3780-3786, 693, 2008.

Yunjie Xu

Research interest

Tumor-targeted therapy

Contact
office
Asan Sci. 337
E-mail
xuyunjie87 at 163.com
Publications
  • Park, M.; Sunwoo, K.; Kim, Y-J.; Won, M.; Xu, Y.; Kim, J.; Pu, Z.; Li, M.; Kim, J. Y.; Seo, J. H.; Kim, J. S. Cutting Off H+ Leaks on Inner Mitochondrial Membrane: A Proton Modulation Approach to Selectively Eradicate Cancer Stem Cells. J. Am. Chem. Soc. 2023, in press.
  • Xiong, H.; Xu, Y.; Kim, B.; Rha, H.; Zhang, B.; Li, M.; Yang, G-F.; Kim, J. S. Photo-Controllable Biochemistry: Exploiting Photocages in the Phototherapeutic Window. Chem 2023, 9, 29-64.
  • Li, M.; Kim, J.; Xu, Y.; Kim, J. S. An acid-activatable nanosensitizer library realizes tunable pyroptosis activation in tumors, Matter. 2023, 6,7-29.
    • MORE VIEW
    • Li, M.; Xu, Y.; Rhee, H-W; Kim, J. S. Deep-red-light photocatalytic protein proximity labelling, Chem. 2022, 8, 3159-3174.
    • Li, M.; Xu, Y.; Peng, X.; Kim, J. S. From Low to No O2-Dependent Hypoxia Photodynamic Therapy (hPDT): A New Perspective. Acc. Chem. Res. 2022, 55, 3253-3264.
    • Xu, Y.; Xiong, H.; Zhang, B.; Lee, I.; Xie, J.; Li, M.; Zhang, H.; Kim, J. S., Photodynamic Alzheimer’s disease therapy: From molecular catalysis to photo-nanomedicine. Coordin. Chem. Rev. 2022, 470, 214726.
    • Li, C.; Guan, X.; Zhang, X.; Zhou, D.; Son, S.; Xu, Y.; Deng, M.; Guo, Z.; Sun, Y.; Kim, J. S., NIR-II bioimaging of small molecule fluorophores: From basic research to clinical applications. Biosensors and Bioelectronics., 2022, 216, 114620.
    • Li, M.; Xu, Y., Pu, Z., Xiong, T., Huang, H., Long, S., Son, S., Yu, L., Singh, N., Tong, Y., Sessler, J. L., Peng, X., Kim, J. S., Photoredox catalysis may be a general mechanism of photodynamic therapy. Proc. Natl. Acad. Sci. U.S.A. 2022, 119, e2210504119.
    • Yu, L.; Xu, Y.; Pu, Z.; Kang, H.; Li, M.; Sessler, J. L.; Kim, J. S., Photocatalytic Superoxide Radical Generator that Induces Pyroptosis in Cancer Cells. J. Am. Chem. Soc. 2022, 144, 11326-11337.
    • Li, M.; Gebremedhin, K. H.; Ma, D.; Pu, Z.; Xiong, T.; Xu, Y.; Kim, J. S.; Peng, X., Conditionally Activatable Photoredox Catalysis in Living Systems. J. Am. Chem. Soc. 2022, 144, 163-173.
    • Y. Xu, Y. Wang, J. An, A. C. Sedgwick, M. Li, J. Xie, W. Hu, J. Kang, S. Sen, A. Steinbrueck, B. Zhang, L. Qiao, S. Wageh, J. F. Arambula, L. Liu, H. Zhang, J. L. Sessler, J. S. Kim, ‘2D-Ultrathin MXene/DOXjade Platform for Iron Chelation Chemo-photothermal Therapy’ Bioact. Mater. 76-85, 14, 2022.
    • J. Xie, Y. Wang, W. Choi, P. Jangili, Y. Ge, Y. Xu, J. Kang, L. Liu, B. Zhang, Z. Xie, J. He, N. Xie, G. Nie, H. Zhang, J. S. Kim, ‘Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies’ Chem. Soc. Rev. 9152-9201, 50, 2021.
    • Piao J, Liu S, Xu Y, et al. ‘Ezrin protein overexpression predicts the poor prognosis of pancreatic ductal adenocarcinomas’ Exp. Mol. Pathol., 98(1), 1-6, 2015.
    • Qu X, Sheng J, Shen L, Su J, Xu Y, Xie Q, Wu Y, Zhang X, Sun L. ‘Autophagy inhibitor chloroquine increases sensitivity to cisplatin in QBC939 cholangiocarcinoma cells by mitochondrial ROS’ Plos one, 16, 12(3), 2017.
    • Jin A, Xu Y, Liu S, Jin T, Li Z, Jin H, Lin L, Lin Z, ‘Sineoculis homeobox homolog 1 protein overexpression as an independent biomarker for pancreatic ductal adenocarcinoma’ Exp. Mol. Pathol., 96(1), 54-60, 2014.
    • Yunjie Xu, Weinan Gao, Yong Zhang et al, ‘ABT737 reverses cisplatin resistance via targeting glucose metabolism of human ovarian cancer cells’ Int. J. Oncol., 53(3), 1055-1068, 2018.