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신진우(Jinwoo Shin)

Research interest

Organic synthesis & Neurodegenerative Disease

Contact
office
Asan Sci. 337
E-mail
blackhock10@korea.ac.kr
Publications
  • J. M. An, H. Moon, P. Verwilst, J. Shin, B. M. Park, C. Park, J. S. Kim, S. G. Yeo, H. Y. Kim, D. Kim ‘Human Glioblastoma Visualization: Triple Receptor-targeting Fluorescent Complex of Dye, SIWV Tetra-peptide, and Serum Albumin Protein’ ACS Sensors, 2021 (in press)
  • J.Shin, Y. Xu, S. Koo, J. H. Lim, J. Y. Lee, A. Sharma, Y. Sun, J. S. Kim, ‘Mitochondria-targeted Nanotheranostic: Harnessing Single Laser Activated Dual Photo-therapeutic Processing for Hypoxic Tumor Treatment’ Matter (Cell Press), 2021 (in press)
  • C. Liu, J. Shin, S. Son, Y. Choe, N. Farokhzad, Z. Tang, Y. Xiao, N. Kong, T. Xie, J. S. Kim, W. Tao, ‘Advances in Pnictogens and Their Compounds in Medicinal Chemistry: Evolution from Erstwhile Drugs to Layered Photonic Nanomedicine’ Chem. Soc. Rev., 2021, 50, 2260-2279.
    • S. Son, J. H. Kim, X. Wang, C. Zhang, S. A. Yoon, J. Shin, A. Sharma, M. H. Lee, L. Cheng, J. Wu, J. S. Kim, ‘Multifunctional sonosensitizers in sonodynamic cancer therapy’ Chem. Soc. Rev., 2020, 49, 3244-3261.
    • B. Chen, W. Gong, Z. Yang, W. Pan, P. Verwilst, J. Shin, W. Yan, L. Liu, J. Qu, J. S. Kim, ‘STORM imaging of mitochondrial dynamics using a vicinal-dithiol-proteinstargeted probe’ Biomaterials, 2020, 243, 119938.
    • P. Liu, W. Fu, P. Verwilst, M. Won, J. Shin, Z. Cai, B. Tong, J. Shi, Y. Dong, J. S. Kim, ‘MDM2-Associated Clusterization-Triggered Emission and Apoptosis Induction Effectuated by a Theranostic Spiropolymer’ Angew. Chem. Int. Ed., 2020, 132, 1-6.
    • J. Shin, P. Verwilst, H. Choi, S. Kang, J. Han, N. H. Kim, J. G. Choi, M. S. Oh, J. S. Hwang, D. Kim, I. M.-Jung, J. S. Kim ‘Harnessing Intramolecular Rotation to Enhance Two-photon Imaging of Aβ Plaques Through Minimizing Background Fluorescence’ Angew. Chem. Int. Ed., 2019, 58, 5648-5652.
    • Y. He, J. Shin, W. Gong, P. Das, J. Qu, Z. Yang, W. Liu, C. Kang, J. Qu, J. S. Kim, ‘Dual-functional fluorescent molecular rotor for endoplasmic reticulum microviscosity imaging during reticulophagy’ Chem. Commun., 2019, 55, 2453-2456.
    • Y. Zhou, M. Maiti, A. Sharma, M. Won, L. Yu, L. X. Miao, J. Shin, A. Podder, K. N. Bobba, J. Han, S. Bhuniya, J. S. Kim, ‘Azo-based small molecular hypoxia responsive theranostic for tumor-specific imaging and therapy’ J. Control Rel., 2018, 288, 14-22.
    • H. S. Jung, P. Verwilst, A. Sharma, J. Shin, J. L. Sessler, J. S. Kim, ‘Organic molecule-based photothermal agents: an expanding photothermal universe’ Chem. Soc. Rev., 2018, 47, 2280-2297.
    • Z. Yang, D. H. Kang, H. Lee, J. Shin, W. Yan, B. Rathore, H.-R. Kim, S. J. Kim, H. Singh, L. Liu, J. Qu, C. Kang, J. S. Kim, \'A Fluorescent Probe for STED Super-Resolution Imaging of Membrane Vicinal-Dithiol-Proteins (VDPs)\' Bioconj. Chem., 2018, 29, 1446-1453.
    • J.-H. Zhu, C. Yu, Y. Chen, J. Shin, Q.-Y. Cao, J. S. Kim, ‘A self-assembled amphiphilic imidazole-based ATP probe’ Chem. Commun., 2017, 53, 4342-4345.

심인섭(Inseob Shim)

Research interest

Organic synthesis

Contact
office
In military service
E-mail
imagine45@korea.ac.kr
Publications
  • P. Jangili, M. Won, S. J. Kim, J. Chun, I. Shim, C. Kang, W. X. Ren, and J. S. Kim, ‘Binary drug reinforced first small molecule-based prodrug for synergistic anti-cancer effect’ ACS Appl. Bio Mat. 2019 (in press).
  • R. Kumar, A. Sharma, H. Singh, P. Suating, H. S. Kim, K. Sunwoo, I. Shim, B. C. Gibb, J. S. Kim ‘Revisiting Fluorescent Calixarenes: From Molecular Sensors to Smart Materials’ Chem. Rev. 2019 (in press).
  • P. Jangili, M. Won, S. J. Kim, J. Chun, I. Shim, C. Kang, W. X. Ren, J. S. Kim, ‘Binary drug reinforced first small molecule-based prodrug for synergistic anti-cancer effect’ Chem. Comm. 2019 (submitted).
    • S. Samanta, W. Gong, W. Li, A. Sharma, I. Shim, W. Zhang, P. Das, W. Pan, L. Liu, Z. Yang, J. Qu, J. S. Kim, ‘Organic fluorescent probes for stochastic optical reconstruction microscopy (STORM): Recent highlights and future possibilities’ Coord. Chem. Rev. 17-34, 380, 2019.
    • K. N. Bobba, M. Won, I. Shim, N. Velusamy, Z. Yang, Junle Qu, J. S. Kim, S. Bhuniya, ‘BODIPY based Two Photon Fluorescent Probe Validates Tyrosinase Activity in Live Cells’ Chem. Commun., 11213-11216, 53, 2017.

손수빈(Subin Son)

Research interest

Drug Delivery System & Sonodynamic Therapy

Contact
office
Asan Sci. 548B
E-mail
babbage91@korea.ac.kr
Publications
  • C. Liu, J. Shin, S. Son, Y. Choe, N. Farokhzad, Z. Tang, Y. Xiao, N. Kong, T. Xie, J. S. Kim, W. Tao ‘Pnictogens in medicinal chemistry: evolution from erstwhile drugs to emerging layered photonic nanomedicine’ Chem. Soc. Rev. 2021, 50, 2260-2279 (DOI: 10.1039/D0CS01175D)
  • M. Won, M. Li, H. S. Kim, P. Liu, S. Koo, S. Son, J. H. Seo, J. S. Kim ‘Visible to mid IR: A library of multispectral diagnostic imaging’ Coord. Chem. Rev., 2021, 426, 213608 (DOI: 10.1016/j.ccr.2020.213608).
  • J. Zhou, P. Jangili, S. Son, M. S. Ji, M. Won, J. S. Kim, ‘Fluorescent Diagnostic Probes in Neurodegenerative Diseases’ Adv. Mater. 2020, 32, 2001945 (DOI: 10.1002/adma.202001945).
    • S. Son, J. H. Kim, X. Wang, C. Zhang, S. A. Yoon, J. Shin, A. Sharma, M. H. Lee, L. Cheng, J. Wu, J. S. Kim, ‘Multifunctional sonosensitizers in sonodynamic cancer therapy’ Chem. Soc. Rev. 2020, 49, 3244 (DOI: 10.1039/C9CS00648F).
    • L-X. Huang, Q. Guo, Y. Chen, P. Verwilst, S. Son, J-B. Wu, Q-Y. Cao and J. S. Kim ‘Nanomolar detection of adenosine triphosphate (ATP) using a nanostructured fluorescent chemosensing ensemble’ Chem. Commun. 2019, 55, 14135-14138 (DOI: 10.1039/C9CC08054F).
    • S. Son, M. Won, O. Green, N. Hananya, A. Sharma, Y. Jeon, J. H. Kwak, J. L. Sessler, D. Shabat, J. S. Kim, ‘Chemiluminescent Probe for the In Vitro and In Vivo Imaging of Cancers Over-expressing NQO1’ Angew. Chem. Int. Ed. 2019, 58, 1739-1743 (DOI: 10.1002/anie.201813032).
    • M. V. Bay, N. K. Hien, S. Son, N. D. Trinh, N. T. Trung, P. C. Nam, J. S. Kim, D. T. Quang, ‘Hg2+-promoted spirolactam hydrolysis reaction: a design strategy for highly selective sensing of Hg2+ over other metal ions in aqueous media’ Sensors 2019, 19, 128, 19 (DOI: 10.3390/s19010128).
    • M. H. Lee, A. Sharma, M. J. Chang, J. Lee, S. Son, J. L. Sessler, C. Kang, J. S. Kim, ‘Fluorogenic Reaction-Based Prodrug Conjugates as Targeted Theranostics’ Chem. Soc. Rev. 2018, 47, 28-52 (DOI: 10.1039/C7CS00557A).

Le Yu

Research interest

Drug Delivery System & NIR fluorescence probe

Contact
office
Asan Sci. 548B
E-mail
yule19931115@163.com
Publications
  • L. Yu, J. F. Zhang, M. Li, Y. Zhou, P. Verwilst, J. S. Kim, ‘A combined viscosity-restricted intramolecular motion and mitochondrial targeting leads to selective tumor visualization’ Chem. Commun., DOI: 10.1039/D0CC02943B, 2020.
  • L. Yu, P. Verwilst, I. Shim, Y. Q. Zhao, Y. Zhou, J. S. Kim, ‘Fluorescent visualization of nucleolar G-Quadruplex RNA and dynamics of endonuclear viscosity’ Biomaterials, 2020 (in press).
    • Y.Q. He, L.X. Miao, L. Yu, Q.L. Chen, Y.M. Qiao, J.F. Zhang, Y. Zhou ‘A near-infrared fluorescent probe for detection of exogenous and endogenous hydrogen peroxide in vivo’ Dyes & Pigm., 160-165, 168, 2019.
    • L. Yu, Y.M. Qiao, L.X. Miao, Y.Q. He, Y. Zhou ‘Recent progress in fluorescent and colorimetric sensors for the detection of ions and biomolecules’ Chinese Chemical Lett., 1545-1559, 29, 2018.
    • Y. Zhou, M. Maiti, A. Sharma, M. Won, L. Yu, L.X. Miao, J. Shin, A. Podder, K.N. Bobba, J. Hand, S. Bhuniya, J.S. Kim ‘Azo-based small molecular hypoxia responsive theranostic for tumorspecific imaging and therapy’ Journal of Controlled Release, 14-22, 288, 2018.

김지현(Ji Hyeon Kim)

Research interest

Organic synthesis, Drug delivery system, Cancer stem cell

Contact
office
Asan Sci. 238
E-mail
jshyeon1@korea.ac.kr
Publications
  • X. Zhang, S. Koo, J. H. Kim, X. Huang, N. Kong, L. Zhang, J. Xue, M. B. Harris, W. Tao, J. S. Kim, ‘Nanotherapeutic Platforms in Bone-Related Diseases: From Chemistry to Applications’ Matter (Cell press), 2021 (in press).
  • J. Zhang, J. Kan, Y. Sun, M. Won, J. H. Kim, W. Zhang, J. Zhou, Z. Qian, J. S. Kim ‘Nanoliposomal Ratiometric Fluorescent Probe toward ONOO Flux’ ACS Appl. Bio Mater. 2080-2088, 4, 2021.
  • A. Sharma, R. Singh, G. P. Kini, J. H. Kim, M. Parashar, M. Kim, M. Kumar, J. S. Kim, J-J. Lee ‘Side-Chain Engineering of Diketopyrrolopyrrole-based Hole-Transport Materials to Realize High-Efficiency Perovskite Solar Cells’ ACS Appl. Mater. Inter. 7405-7415, 60, 2021.
    • J. Han, M. Won, J. H. Kim, E. Jung, J. Paramesh, K. Min, J. S. Kim, ‘Cancer Stem Cell-targeted Bio sensing & Chemotherapeutic Perspective’ Chem. Soc. Rev., 49, 7856-7878, 2020..
    • S. Son, J. H. Kim, X. Wang, C. Zhang, S. A. Yoon, J. Shin, A. Sharma, M. H. Lee, L. Cheng, J. Wu, J. S. Kim, ‘Multifunctional sonosensitizers in sonodynamic cancer therapy’ Chem.Soc.Rev., 3244-3261, 49, 2020.
    • J. Xie, T. Fan, J. H. Kim, Y. Xu, Y. Wang, W. Liang, L. Qiao, Z. Wu, Q. Liu, W. Hu, N. Yin, L. Yang, L. Liu, J. S. Kim, H. Zhang, ‘Emetine Loaded Black Phosphorus Hydrogel Sensitizes Tumor to Photothermal Therapy through Inhibition of Stress Granule Formation’ Adv. Func. Mater., 30, 2003891, 2020.
    • M. Li, Y. Shao, J.H. Kim, Z. Pu, X. Zhao, H. Huang, T. Xiong, Y. Kang, G.-Z. Li, K. Shao, J. Fan, J. W. Foley, J. S. Kim, X. Peng, ‘Unimolecular Photodynamic O2-Econemizer to Overcome Hypoxia Resistance in Phototherapeutic’ J. Am. Chem. Soc., 5380-5388, 142, 2020.
    • B. Rathore, K. Sunwoo, P. Jangili, J. Kim, J. H. Kim, M. Huang, J. Xiong, A. Sharma, Z. Yang, J. Qu, and J. S. Kim ‘Nanomaterial designing strategies related to cell lysosome and their biomedical applications: A review’ Biomaterials, 211, 25-47, 2019.
    • H. Singh, J.-Y. Lim, A. Sharma, D. W. Yoon, J. H. Kim, Z. Yang, J. Qu, J. Kim, J. S. Kim, ‘A pH-Responsive Glycyrrhetinic acid-Modified Small Molecular Conjugate for NIR Imaging of Hepatocellular Carcinoma (HCC)’ ChemBioChem 614-620, 20, 2019.

안주성 (Jusung An)

Research interest

Alzhemer’s Disease & Fluorophore & Photodynamic modulation

Contact
office
Asan Sci. 346
E-mail
jusung0614@korea.ac.kr
Publications
  • J. An, P. Jangili, S. Lim, Y. K. Kim, P. Verwilst, J. S. Kim ‘Multichromatic Fluorescence towards Aberrant Proteinaceous Aggregates utilizing Benzimidazole-based ICT Fluorophores’ J. Incl. Phenom. Macrocycl. Chem., 2021 (in press).
  • S. Wang, W. X. Ren, J-T. Hou, M. Won, J. An, X. Chen, J. Shu and J. S. Kim ‘Fluorescence imaging of pathophysiological microenvironments’ Chem. Soc. Rev., 2021 (in press).

  • E. Jung, I. Shim, J. An, M. S. Ji, P. Jangili, S-G. Chi, J. S. Kim ‘Phenylthiourea-conjugated BODIPY as an efficient photosensitizer for tyrosinase-positive melanoma-targeted photodynamic therapy’ ACS Appl. Bio Mater., 2021, 4, 2120-2127.

    • Y. Ren, A. C. Sedgwick, J. Chen, G. Thiabaud, C. V. Chau, J. An, J. F. Arambula, X-P. He, J. S. Kim, J. L. Sessler, C. Liu ‘Manganese(II) Texaphyrin: A Paramagnetic Photoacoustic Contrast Agent Activated by Near-IR Light’ J. Am. Chem. Soc., 2020, 142, 16156-16160.

    • J. Li, Y. Zhang, P. Wang, L. Yu, J. An, G. Deng, Y. Sun, J. S. Kim ‘Reactive Oxygen Species, Thiols and Enzymes Activable AIEgens from Single Fluorescence Imaging to Multifunctional Theranostics’ Coord. Chem. Rev., 2020, 427, 213559.

    • Y. Xu, Y. Zhang, J. Li, J. An, C. Li, S. bai, A. Sharma, G. Deng, J. S. Kim, Y. Sun, ‘NIR-II Emissive Multifunctional AIEgen with Single Laser-Activated Synergistic Photodynamic/Photothermal Therapy of Cancers and Pathogens’ Biomaterials, 2020, 259, 120315.

    • Y.-H. Zhang, X. Li, L. Huang, H. S. Kim, J. An, M. Lan, Q.-Y. Cao, J. S. Kim, ‘AIE based GSH activatable photosensitizer for imaging-guided photodynamic therapy’ Chem. Commun., 2020, 56, 10317-10320.

    • Z. Xie, T. Fan, J. An, W. Choi, Y. Duo, Y. Ge, B. Zhang, G. Nie, N. Xie, H. Zhang, J. S. Kim, ‘Emerging combination strategies with phototherapy in cancer nanomedicine’ Chem. Soc. Rev., 2020, 49, 8065-8087.

    • J. Wu, L. Jiang, P. Verwilst, J. An, H. Zeng, L. Zeng, G. Niu, J. S. Kim ‘A colorimetric and fluorescence lighting-up sensor based on ICT coupled with PET for rapid, specific and sensitive detection of nitrite in food’ Chem. Commun., 2019, 55, 9947-9950.