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Le Yu

Research interest

Drug Delivery System & Photo Therapy

Contact
office
Asan Sci. 548B
E-mail
yule19931115 at 163.com
Publications
  • L. Yu, Y. Xu, Z. Pu, H. Kang, M. Li*, J. L. Sessler*, J. S. Kim* ‘Photocatalytic Superoxide Radical Generator that Induces Pyroptosis in Cancer Cells’ J. Am. Chem. Soc., 2022, 144, 11326−11337
  • P. Wang, L. Yu, J. Gong, J. Xiong, S. Zi, H. Xie, F. Zhang, Z. Mao*, Z. Liu*, J. S. Kim*, ‘An Activity-Based Fluorescent Probe for Imaging Fluctuations of Peroxynitrite (ONOO- ) in the Alzheimer’s Disease Brain’ Angew. Chem. Int. Ed., 2022, 61, e202206894
    • MORE VIEW
    • D. Wang, W. Gu, W. Chen, J. Zhou*, L. Yu, B. K. Kim, X. Zhang*, J. S. Kim*, ‘Advanced nanovaccines based on engineering nanomaterials for accurately enhanced cancer immunotherapy’ Coord. Chem. Rev., 2022, 472, 214788
    • Y. Zhang, X. Zhang, H. Yang, L. Yu, Y. Xu, A. Sharma, P. Yin, X. Li,* J. S. Kim*, Y. Sun*, ‘Advanced biotechnology-assisted precise sonodynamic therapy’ Chem. Soc. Rev., 2021, 50, 11227–11248
    • H. Chu, L. Yang, L. Yu, J. Kim, J. Zhou*, M. Li*, J. S. Kim*, ‘Fluorescent probes in public health and public safety’ Coord. Chem. Rev., 2021, 449, 214208.
    • L. Huang, S. Zhao, J. Wu , L. Yu, N. Singh, K. Yang, M. Lan*, P. Wang*, J. S. Kim*, ‘Photodynamic therapy for hypoxic tumors: Advances and perspectives’ Coord. Chem. Rev., 2021, 438, 213888.
    • J. Li, Y. Zhang, P. Wang , L. Yu, J. An, G. Deng, Y. Sun*, J. S. Kim*, ‘Reactive oxygen species, thiols and enzymes activable AIEgens from single fluorescence imaging to multifunctional theranostics’ Coord. Chem. Rev., 2021, 427, 213559.
    • Y. Q. Zhao, J. Duan, L. Yu, I. Kim, Y. Wang, Y. C. Ma, C. G. Zou, Y. Zhou, J. F. Zhang, J. S. Kim ‘Metabolic iron detection through divalent metal transporter 1 and ferroportin mediated cocktail fluorogenic probes’ Chem. Commun., 2021, 57, 7902–7905.
    • L. Yu, J. F. Zhang, M. Li, Y. Zhou, P. Verwilst, J. S. Kim, ‘A combined viscosity-restricted intramolecular motion and mitochondrial targeting leads to selective tumor visualization’ Chem. Commun., 2020, 56, 6684-6687
    • L. Yu, P. Verwilst, I. Shim, Y. Q. Zhao, Y. Zhou, J. S. Kim, ‘Fluorescent visualization of nucleolar G-Quadruplex RNA and dynamics of endonuclear viscosity’ CCS Chem. 2020, 2, 2725–2739.
    • Y.Q. He, L.X. Miao, L. Yu, Q.L. Chen, Y.M. Qiao, J.F. Zhang, Y. Zhou ‘A near-infrared fluorescent probe for detection of exogenous and endogenous hydrogen peroxide in vivo’ Dyes & Pigm., 160-165, 168, 2019.
    • L. Yu, Y.M. Qiao, L.X. Miao, Y.Q. He, Y. Zhou ‘Recent progress in fluorescent and colorimetric sensors for the detection of ions and biomolecules’ Chinese Chemical Lett., 1545-1559, 29, 2018.
    • Y. Zhou, M. Maiti, A. Sharma, M. Won, L. Yu, L.X. Miao, J. Shin, A. Podder, K.N. Bobba, J. Hand, S. Bhuniya, J.S. Kim ‘Azo-based small molecular hypoxia responsive theranostic for tumorspecific imaging and therapy’ Journal of Controlled Release, 14-22, 288, 2018.

안주성 (Jusung An)

Research interest

Small-molecule fluorescence optical imaging

Contact
office
Asan Sci. 346
E-mail
jusung0614 at korea.ac.kr
Publications
  • Y. Yang, M. Ma, L. Shen, J. An, E. Kim, H. Liu, M. Jin, S. Wang, J. Zhang, J. S. Kim, C. Yin, ‘A Fluorescent Probe for Investigating the Role of Biothiols in Signaling Pathways Associated with Cerebral Ischemia-Reperfusion Injury’ Angew. Chem., Int. Ed. 2023, in press.
  • H. -W. Kwon, J. An, J. S. Kim, I. -C. Kang, ‘Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells’ Biochem. Biophys. Rep. 2023, 35, 101517. Read here
  • M. A. Tekalgne, H. H. Do, T. V. Nguyen, Q. V. Le, J. An, S. H. Hong, S. H. Ahn, H. Kang, J. S. Kim, S. Y. Kim, ‘Efficient Electrocatalysts for Hydrogen Evolution Reaction using Heteroatom-Doped MXene Nanosheet’ Int. J. Energy Res. 2023, 2023, 8980888. Read here
    • MORE VIEW
    • J. Shin, J. An, J. Kim, Y. Noh, P. Jangili, J. S. Kim, ‘Ratiometric Fluorescent Chemosensors: Photophysical/Chemical Mechanism Principles and Design Strategies’ Fluorescent Chemosensors 2023, 124-159.
    • Z. Zunbul, J. An, H. Aziz, J. Shin, S. Lim, Y. K. Kim, J. S. Kim, ‘Tailoring hydrophobicity of Thioflavin T to optimize Aβ fibril bioimaging’ Adv. Nanobiomed. Res. 2023, 3, 2200161. Read here
    • Z. Liu, Z. Han, X. Jin, J. An, J. Kim, W. Chen, J. S. Kim, J. Zheng, J. Deng, ‘Regulating the microenvironment with nanomaterials: Potential strategies to ameliorate COVID-19’ Acta Pharm. Sin. B 2023 (in press). Read here
    • J. An, H. Hong, M. Won, H. Rha, Q. Ding, N. Kang, H. Kang, J. S. Kim, ‘Mechanical stimuli-driven cancer therapeutics’ Chem. Soc. Rev. 2023, 52, 30-46. Read here
    • Y. Xu, C. Li, J. An, X. Ma, J. Yang, L. Luo, Y. Deng, J. Kim, Y. Sun, ‘Construction of a 980 nm laser-activated Pt(II) metallacycle nanosystem for efficient and safe photo-induced bacteria sterilization’ Sci. China Chem. 2023, 66, 155-163. Read here
    • C. Zhang, J. An, J. Wu, W. Liu, H. Rha, J. S. Kim, P. Wang, ‘Structural modification of NIR-II fluorophores for angiography beyond 1300 nm: Expanding the xanthene universe’ Biosens. Bioelectron., 2022, 217, 114701. Read here
    • X. He, J.-T. Hou, X. Sun, P. Jangili, J. An, Y. Qian, J. S. Kim, J. Shen ‘NIR-II Photo-Amplified Sonodynamic Therapy Using Sodium Molybdenum Bronze Nanoplatform Against Subcutaneous Staphylococcus Aureus Infection’ Adv. Func. Mat., 2022, 38, 2203964. Read here
    • J. An, P. Verwilst, H. Aziz, J. Shin, S. Lim, I. Kim, Y. K. Kim, J. S. Kim, ‘Picomolar-Sensitive β-Amyloid Fibril Fluorophores by Tailoring the Hydrophobicity of Biannulated π-Elongated Dioxaborine-Dyes’ Bioact. Mater., 2022, 13, 239-248. Read here

    • Y. Xu, Y. Wang, J. An, A. C. Sedgwick, M. Li, J. Xie, W. Hu, J. Kang, S. Sen, A. Steinbrueck, B. Zhang, L. Qiao, S. Wageh, J. F. Arambula, L. Liu, H. Zhang, J. L. Sessler, J. S. Kim, ‘2D-Ultrathin MXene/DOXjade Platform for Iron Chelation Chemo-photothermal Therapy’ Bioact. Mater., 2022, 14, 76-85. Read here

    • Z. Mao, J. Xiong, P. Wang, J. An, F. Zhang, Z. Liu, J. S. Kim, ‘Activity-based Fluorescence Probes for Pathophysiological Peroxynitrite Fluxes’ Coord. Chem. Rev., 2022, 454, 214356. Read here

    • N. Singh, S. Son, J. An, I. Kim, M. Choi, N. Kong, W. Tao, J. S. Kim, ‘Nanoscale porous organic polymers for drug delivery and advanced cancer theranostics’ Chem. Soc. Rev., 2021, 50, 12883-12896. Read here

    • J. An, P. Jangili, S. Lim, Y. K. Kim, P. Verwilst, J. S. Kim ‘Multichromatic Fluorescence towards Aberrant Proteinaceous Aggregates utilizing Benzimidazole-based ICT Fluorophores’ J. Incl. Phenom. Macrocycl. Chem., 2021, 101, 205-215. Read here

    • S. Wang, W. X. Ren, J-T. Hou, M. Won, J. An, X. Chen, J. Shu and J. S. Kim ‘Fluorescence imaging of pathophysiological microenvironments’ Chem. Soc. Rev., 2021, 50, 8887-8902. Read here

    • E. Jung, I. Shim, J. An, M. S. Ji, P. Jangili, S-G. Chi, J. S. Kim ‘Phenylthiourea-conjugated BODIPY as an efficient photosensitizer for tyrosinase-positive melanoma-targeted photodynamic therapy’ ACS Appl. Bio Mater., 2021, 4, 2120-2127. Read here

    • Y. Ren, A. C. Sedgwick, J. Chen, G. Thiabaud, C. V. Chau, J. An, J. F. Arambula, X-P. He, J. S. Kim, J. L. Sessler, C. Liu ‘Manganese(II) Texaphyrin: A Paramagnetic Photoacoustic Contrast Agent Activated by Near-IR Light’ J. Am. Chem. Soc., 2020, 142, 16156-16160. Read here

    • J. Li, Y. Zhang, P. Wang, L. Yu, J. An, G. Deng, Y. Sun, J. S. Kim ‘Reactive Oxygen Species, Thiols and Enzymes Activable AIEgens from Single Fluorescence Imaging to Multifunctional Theranostics’ Coord. Chem. Rev., 2020, 427, 213559. Read here

    • Y. Xu, Y. Zhang, J. Li, J. An, C. Li, S. bai, A. Sharma, G. Deng, J. S. Kim, Y. Sun, ‘NIR-II Emissive Multifunctional AIEgen with Single Laser-Activated Synergistic Photodynamic/Photothermal Therapy of Cancers and Pathogens’ Biomaterials, 2020, 259, 120315. Read here

    • Y.-H. Zhang, X. Li, L. Huang, H. S. Kim, J. An, M. Lan, Q.-Y. Cao, J. S. Kim, ‘AIE based GSH activatable photosensitizer for imaging-guided photodynamic therapy’ Chem. Commun., 2020, 56, 10317-10320. Read here

    • Z. Xie, T. Fan, J. An, W. Choi, Y. Duo, Y. Ge, B. Zhang, G. Nie, N. Xie, H. Zhang, J. S. Kim, ‘Emerging combination strategies with phototherapy in cancer nanomedicine’ Chem. Soc. Rev., 2020, 49, 8065-8087. Read here

    • J. Wu, L. Jiang, P. Verwilst, J. An, H. Zeng, L. Zeng, G. Niu, J. S. Kim ‘A colorimetric and fluorescence lighting-up sensor based on ICT coupled with PET for rapid, specific and sensitive detection of nitrite in food’ Chem. Commun., 2019, 55, 9947-9950. Read here

김재원 (Jaewon Kim)

Research interest

Organic synthesis & Photodynamic therapy

Contact
office
Asan Sci. 337
E-mail
kcjb2929 at gmail.com
Publications
  • J. Kim, S. Lee, Y. Kim, M. Choi, I. Lee, E. Kim, C. G. Yoon, K. Pu, H. Kang, J. S. Kim ‘In situ self-assembly for cancer therapy and imaging’ Nat. Rev. Mater., 2023, in press.
  • Z. Liu, Z. Han, X. Jin, J. An, J. Kim, W. Chen, J. S. Kim*, J. Zheng*, J. Deng*, ‘Regulating the microenvironment with nanomaterials: Potential strategies to ameliorate COVID-19’ Acta Pharm. Sin. B., 2023, 13(9), 3638-3658.
  • M. Park, K. Sunwoo, Y.-J. Kim, M. Won, Y. Xu, J. Kim, Z. Pu, M. Li*, J. Y. Kim*, J. H. Seo*, J. S. Kim*, ‘Cutting Off H+ Leaks on Inner Mitochondrial Membrane: A Proton Modulation Approach to Selectively Eradicate Cancer Stem Cells.’ J. Am. Chem. Soc., 2023, 8, 4647-4658.
    • MORE VIEW
    • N.Singh, J. Kim, J. Kim, K. Lee, Z. Zunbul, I. Lee, S. G. Chi*, J. S. Kim*, ‘Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications’ Bioact. Mater., 2023, 21, 358-380.
    • S. Son, J. Kim, J. Kim, B. Kim, J. Lee, Y. Kim, M. Li*, H. Kang*, J. S. Kim*, ‘Cancer therapeutics based on diverse energy sources’ Chem. Soc. Rev., 2022, 51, 8201-8215.
    • J. Kim, S. Lee, M. S. Han*, ‘pH-guided fluorescent sensing probe for the discriminative detection of Cl− and Br− in human serum’ Anal. Chim. Acta, 2022, 1210, 339879.
    • L.-X. Huang, Y.-B. He, J. Kim, A. Sharma, Q.-Y. Cao*, J. S. Kim*, ‘Pyridinium-conjugated polynorbornenes for nanomolar ATP sensing using an indicator displacement assay and a PET strategy’ Chem. Commun., 2021, 57, 13530-13533.
    • J. Kim, S. Lee, S. Kim, M. Jung, H. Lee*, M. S. Han*, ‘Development of a fluorescent chemosensor for chloride ion detection in sweat using Ag+-benzimidazole complexes’ Dyes Pigm., 2020, 108291.

Qihang Ding

Research interest

Fabrication of organic small molecule probes in the NIR-II

Contact
office
Asan sci. 238
E-mail
dingqihang at whu.edu.cn
Publications
  • Q. Li, Q. Ding, Y. Li, X. Zeng, Y. Liu, S. Lu, H. Zhou, X. Wang, J.Wu, X. Meng, Z. Denga and Y. Xiao ‘Novel small-molecule fluorophores for in vivo NIR-IIa and NIR-IIb imaging’ Chemical Communications. doi:10.1039/c9cc09865h
  • Y. Li, Y. Liu, Q. Li, X. Zeng, T. Tian, W.Zhou, Y. Cui, X. Wang, X. Cheng, Q. Ding, X. Wang, J. Wu, H. Deng, Y. Li, X. Meng, Z. Deng, X. Honga, and Y. Xiao ‘Novel NIR-II organic fluorophores for bioimaging beyond 1550 nm’ Chemical Science. doi:10.1039/c9sc06567a
  • H. Zhou, W. Yi, A. Li, B. Wang, Q. Ding, L. Xue, X. Zeng, Y. Feng, Q. Li, T. Wang, Y. Li, X. Cheng, L. Tang, Z. Deng, M. Wu, Y. Xiao, and X. Hong ‘Specific Small‐Molecule NIR‐II Fluorescence Imaging of Osteosarcoma and Lung Metastasis’ Advanced Healthcare Materials. doi:10.1002/adhm.201901224
    • MORE VIEW
    • J. Lin, Q. Li, X. Zeng, Z. Chen, Q. Ding, Y. Li, H. Zhou, X. Meng, D. Chen, Z. Deng, X. Hong and Y. Xiao ‘A novel small-molecule near-infrared II fluorescence probe for orthotopic osteosarcoma imaging’ SCIENCE CHINA Chemistry 63, 766 (2020); doi: 10.1007/s11426-019-9685-6

김정륜 (Jungryun Kim)

Research interest

Drug Delivery System, Phototherapeutics

Contact
office
Asan Sci. 548B
E-mail
ryunnkim at korea.ac.kr
Publications
  • J. Kim†, P. Jangili†, J. Kim†, S. Lucia, J. Ryu, R. Prasad, S. Zi, P. Kim, W. Sun and J. S. Kim, Chem. ‘Mitochondrial NIR imaging probe mitigating oxidative damage by targeting HDAC6’ Chem. Commun., 2023, 59, 10109-10112.
  • Z. Mao†, H. Rha†, J. Kim†, X. You, F. Zhang, W. Tao and J. S. Kim, ‘THQ-Xanthene: An Emerging Strategy to Create Next-Generation NIRI/II Fluorophores’ Adv. Sci. 2023, 10, 2301177
  • M. Li†, J. Kim†, H. Rha, S. Son, Y. Xu, J. L. Sessler and J. S. Kim, ‘Photon-Controlled Pyroptosis Activation (PhotoPyro): An Emerging Trigger for Antitumor Immune Response’ J. Am. Chem. Soc. 2023, 145, 11, 6007-6023.
    • MORE VIEW
    • L. Yu†, Y. Xu, J. Kim, J. Lee, J. S. Kim*, ‘A rational design of AIE-active fluorophore for the fingerprint optical detection’ Bull. Korean Chem. Soc., 2023, 1–7.
    • M. Li†, J. Kim, Y. Xu, J. S. Kim*, ‘An acid-activatable nanosensitizer library realizes tunable pyroptosis activation in tumors’ Matter, 2023, 6, 1, 15-18.
    • N.Singh†, J. Kim†, J. Kim†, K. Lee†, Z. Zunbul, I. Lee, S. G. Chi*, J. S. Kim*, ‘Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications’ Bioact. Mater., 2023, 21, 358-380.
    • S. Son†, J. Kim†, J. Kim, B. Kim, J. Lee, Y. Kim, M. Li, H. Kang, J. S. Kim*, ‘Cancer therapeutics based on diverse energy sources’ Chem. Soc. Rev., 2022, 51, 8201-8215.
    • H. Chu, L. Yang, L. Yu, J. Kim, J. Zhou*, M. Li*, J. S. Kim*, ‘Fluorescent probes in public health and public safety’ Coord. Chem. Rev., 214208, 449, 2021.

나현지 (Hyeonji Rha)

Research interest

Type I PDT probes, optically enhanced NIR-II imaging probes

Contact
office
Asan Sci. 238
E-mail
sweethew at korea.ac.kr
Publications
  • Z. Mao, H. Rha, J. Kim, X. You, F. Zhang, W. Tao, and J. S. Kim, ‘THQ-Xanthene: An Emerging Strategy to Create Next-Generation NIRI/II Fluorophores’ Adv. Sci. 2023, 10, 2301177. Read here
  • M. Li, J. Kim, H. Rha, S. Son, M. S. Levine, Y. Xu, J. L. Sessler, and J. S. Kim, ‘Photon-Controlled Pyroptosis Activation (PhotoPyro): An Emerging Trigger for Antitumor Immune Response’ J. Am. Chem. Soc. 2023, 145, 11, 6007-6023. Read here
  • J. An, H. Hong, M. Won, H. Rha, Q. Ding, N. Kang, H. Kang, J. S. Kim, ‘Mechanical stimuli-driven cancer therapeutics’ Chem. Soc. Rev. 2023 (in press). Read here
    • MORE VIEW
    • C. Zhang, J. An, J. Wu, W. Liu, H. Rha, J. S. Kim, P. Wang, ‘Structural modification of NIR-II fluorophores for angiography beyond 1300 nm: Expanding the xanthene universe’ Biosens. Bioelectron., 2022, 12, 217, 114701.
    • H. Xiong, Y. Xu, B. Kim, H. Rha, B. Zhang, M. Li, G.-F. Yang, J. S. Kim, ‘Photo-Controllable Biochemistry: Exploiting the Photocages in Phototherapeutic Window.’ Chem 2023, 9, 29-64.DOI: 10.1016/j.chempr.2022.11.007.
    • H. Singh, D. Sareen, J. M. George, V. Bhardwaj, S. H. Rha, S. J. Lee, S. Sharma, A. Sharma, J. S. Kim, ‘Mitochondria-targeted fluorogenic theranostic agents for cancer therapy’ Coord. Chem. Rev., 2022, 12 , 452, 214283.


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