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손수빈(Subin Son)

Research interest

Drug Delivery System & Sonodynamic Therapy

Asan Sci. 548B
babbage91 at
  • J. Xiong, P. Wang, S. Son, C. Zhong, F. Zhang, Z. Mao, Z. Liu, J. S. Kim, ‘Engineering theranostic platform for synergistic hypoxia-responsive photodynamic and chemotherapies’ Matter 2022, 5, 1502-1519 (DOI: 10.1016/j.matt.2022.02.019).
  • P. Liu, F. Ren, S. Son, M. S. Ji, P. Li, Z. Cai, J. Shi, Y. Liu, Y. Dong, J. S. Kim ‘Mitochondrial targeted AIEgen phototheranostics for bypassing immune barrier via encumbering mitochondria functions’ Biomaterials, 2022, 283, 121409 (DOI: 10.1016/j.biomaterials.2022.121409).
  • N. Singh, S. Son, J. An, I. Kim, M. Choi, N. Kong, W. Tao, J. S. Kim, ‘Nanoscale porous organic polymers for drug delivery and advanced cancer theranostics’ Chem. Soc. Rev. 12883-12896, 50, 2021 (10.1039/D1CS00559F).
    • S. Son, C. Zhang, M. Won, P. Jangili, M. Choi, J. Wu, J. S. Kim ‘Ultrasound activatable antiangiogenic sonosensitizer for VEGFR associated glioblastoma tumor models’ Aggregate, 2021, 2, e97 (DOI:10.1002/agt2.97)
    • C. Liu, J. Shin, S. Son, Y. Choe, N. Farokhzad, Z. Tang, Y. Xiao, N. Kong, T. Xie, J. S. Kim, W. Tao ‘Pnictogens in medicinal chemistry: evolution from erstwhile drugs to emerging layered photonic nanomedicine’ Chem. Soc. Rev. 2021, 50, 2260-2279 (DOI: 10.1039/D0CS01175D)
    • M. Won, M. Li, H. S. Kim, P. Liu, S. Koo, S. Son, J. H. Seo, J. S. Kim ‘Visible to mid IR: A library of multispectral diagnostic imaging’ Coord. Chem. Rev., 2021, 426, 213608 (DOI: 10.1016/j.ccr.2020.213608).
    • J. Zhou, P. Jangili, S. Son, M. S. Ji, M. Won, J. S. Kim, ‘Fluorescent Diagnostic Probes in Neurodegenerative Diseases’ Adv. Mater. 2020, 32, 2001945 (DOI: 10.1002/adma.202001945).
    • S. Son, J. H. Kim, X. Wang, C. Zhang, S. A. Yoon, J. Shin, A. Sharma, M. H. Lee, L. Cheng, J. Wu, J. S. Kim, ‘Multifunctional sonosensitizers in sonodynamic cancer therapy’ Chem. Soc. Rev. 2020, 49, 3244-3261 (DOI: 10.1039/C9CS00648F).
    • L-X. Huang, Q. Guo, Y. Chen, P. Verwilst, S. Son, J-B. Wu, Q-Y. Cao and J. S. Kim ‘Nanomolar detection of adenosine triphosphate (ATP) using a nanostructured fluorescent chemosensing ensemble’ Chem. Commun. 2019, 55, 14135-14138 (DOI: 10.1039/C9CC08054F).
    • S. Son, M. Won, O. Green, N. Hananya, A. Sharma, Y. Jeon, J. H. Kwak, J. L. Sessler, D. Shabat, J. S. Kim, ‘Chemiluminescent Probe for the In Vitro and In Vivo Imaging of Cancers Over-expressing NQO1’ Angew. Chem. Int. Ed. 2019, 58, 1739-1743 (DOI: 10.1002/anie.201813032).
    • M. V. Bay, N. K. Hien, S. Son, N. D. Trinh, N. T. Trung, P. C. Nam, J. S. Kim, D. T. Quang, ‘Hg2+-promoted spirolactam hydrolysis reaction: a design strategy for highly selective sensing of Hg2+ over other metal ions in aqueous media’ Sensors 2019, 19, 128 (DOI: 10.3390/s19010128).
    • M. H. Lee, A. Sharma, M. J. Chang, J. Lee, S. Son, J. L. Sessler, C. Kang, J. S. Kim, ‘Fluorogenic Reaction-Based Prodrug Conjugates as Targeted Theranostics’ Chem. Soc. Rev. 2018, 47, 28-52 (DOI: 10.1039/C7CS00557A).

Le Yu

Research interest

Drug Delivery System & Photo Therapy

Asan Sci. 548B
yule19931115 at
  • Y. Zhang, X. Zhang, H. Yang, L. Yu, Y. Xu, A. Sharma, P. Yin, X. Li,* J. S. Kim*, Y. Sun*, ‘Advanced biotechnology-assisted precise sonodynamic therapy’ Chem. Soc. Rev., 0306-0012, 2021, (in press)
  • H. Chu, L. Yang, L. Yu, J. Kim, J. Zhou*, M. Li*, J. S. Kim*, ‘Fluorescent probes in public health and public safety’ Coord. Chem. Rev., 2021, 449, 214208.
    • L. Huang, S. Zhao, J. Wu , L. Yu, N. Singh, K. Yang, M. Lan*, P. Wang*, J. S. Kim*, ‘Photodynamic therapy for hypoxic tumors: Advances and perspectives’ Coord. Chem. Rev., 2021, 438, 213888.
    • J. Li, Y. Zhang, P. Wang , L. Yu, J. An, G. Deng, Y. Sun*, J. S. Kim*, ‘Reactive oxygen species, thiols
    • and enzymes activable AIEgens from single fluorescence imaging to multifunctional theranostics’ Coord. Chem. Rev., 2021, 427, 213559.
    • Y. Q. Zhao, J. Duan, L. Yu, I. Kim, Y. Wang, Y. C. Ma, C. G. Zou, Y. Zhou, J. F. Zhang, J. S. Kim ‘Metabolic iron detection through divalent metal transporter 1 and ferroportin mediated cocktail fluorogenic probes’ Chem. Commun., 2021, 57, 7902–7905.
    • L. Yu, J. F. Zhang, M. Li, Y. Zhou, P. Verwilst, J. S. Kim, ‘A combined viscosity-restricted intramolecular motion and mitochondrial targeting leads to selective tumor visualization’ Chem. Commun., 2020, 56, 6684-6687
    • L. Yu, P. Verwilst, I. Shim, Y. Q. Zhao, Y. Zhou, J. S. Kim, ‘Fluorescent visualization of nucleolar G-Quadruplex RNA and dynamics of endonuclear viscosity’ CCS Chem. 2020, 2, 2725–2739.
    • Y.Q. He, L.X. Miao, L. Yu, Q.L. Chen, Y.M. Qiao, J.F. Zhang, Y. Zhou ‘A near-infrared fluorescent probe for detection of exogenous and endogenous hydrogen peroxide in vivo’ Dyes & Pigm., 160-165, 168, 2019.
    • L. Yu, Y.M. Qiao, L.X. Miao, Y.Q. He, Y. Zhou ‘Recent progress in fluorescent and colorimetric sensors for the detection of ions and biomolecules’ Chinese Chemical Lett., 1545-1559, 29, 2018.
    • Y. Zhou, M. Maiti, A. Sharma, M. Won, L. Yu, L.X. Miao, J. Shin, A. Podder, K.N. Bobba, J. Hand, S. Bhuniya, J.S. Kim ‘Azo-based small molecular hypoxia responsive theranostic for tumorspecific imaging and therapy’ Journal of Controlled Release, 14-22, 288, 2018.

김지현(Ji Hyeon Kim)

Research interest

Cancer stem cells, Drug delivery system, Porous organic polymers

Asan Sci. 238
jshyeon1 at
  • H. Lei, J. H. Kim, S. Son, L. Chen, Zi. Pei, Y. Yang, Z. Liu, L. Cheng, J. S. Kim ‘Immunosonodynamic therapy (iSDT) designed with activatable sonosensitizer and immune stimulant imiquimod’ ACS Nano 2022 (in press).
  • H. Kim, J. Shin, D. W. Kang, Y. Kim, J. H. Kim, M. Kang, J. H. Choe, S. Park, J. S. Kim, C. S. Hong, ‘Photocatalytic detoxification of a sulfur mustard simulant under realistic conditions by imidazoline-based porous organic polymer composites’ Cell Rep. Physical Science, 2022 (in press)
  • P. Jangili, N. Kong, J. H. Kim, J. Zhou, H. Liu, X. Zhang, W. Tao, J. S. Kim, ‘DNA Damage Response Targeting Mitochondrial Induced Multifunctional Prodrug Strategy for Self-defensive Tumor Therapy’ Angew. Chem. Int. Ed. 2022, 61, e20211702022. (Cover)
    • J. H. Kim, D. W. Kang, H. Yun, M. Kang, N. Singh, J. S Kim, C. S. Hong ‘Post-synthetic modifications in porous organic polymers for biomedical and related applications’ Chem. Soc. Rev. 2021, 51, 43-56.
    • M. Won, J. H. Kim, M. S. Ji, J. S. Kim, ‘ROS activatable prodrug for ALDH overexpressed cancer stem cells’ Chem. Commun. 2022, 58, 72-75.
    • J. H. Kim, H. Yun, D. W. Kang, J. Shin, M. Kang, N. Singh, J.-E. Jeong, C. S. Hong, J. S. Kim, ‘Isomeric sp2-Carbon Porous Organic Polymer-mediated Photo- and Sono-catalytic Detoxification of Sulfur Mustard under Ambient Conditions’ Matter (Cell Press) 2021, 4, 3774–3785.
    • J. H. Kim, P. Verwilst, M. Won, J. Lee, J. L. Sessler, J. Han, J. S. Kim, ‘A small molecule strategy for targeting cancer stem cells in hypoxic microenvironments and preventing tumorigenesis’ J. Am. Chem. Soc. 2021, 143, 35, 14115–14124. (Cover)
    • R. H. Kang, Y. Kim, J. H. Kim, N. H. Kim, H. M. Ko, S.-H. Lee, I. Shim, J. S. Kim, H.-J. Jang, D. Kim ‘Self-activating Therapeutic Nanoparticle: A Targeted Tumor Therapy using ROS Self-generation and Switch-on Drug Release’ ACS Appl. Mater. Inter. 13, 30359–30372, 2021.
    • X. Zhang, S. Koo, J. H. Kim, X. Huang, N. Kong, L. Zhang, J. Xue, M. B. Harris, W. Tao, J. S. Kim, ‘Nanoscale materials-based platforms for the treatment of bone-related diseases’ Matter (Cell Press), 2727–2764, 4, 2021.
    • J. Zhang, J. Kan, Y. Sun, M. Won, J. H. Kim, W. Zhang, J. Zhou, Z. Qian, J. S. Kim ‘Nanoliposomal Ratiometric Fluorescent Probe toward ONOO Flux’ ACS Appl. Bio Mater. 2080-2088, 4, 2021.
    • A. Sharma, R. Singh, G. P. Kini, J. H. Kim, M. Parashar, M. Kim, M. Kumar, J. S. Kim, J-J. Lee ‘Side-Chain Engineering of Diketopyrrolopyrrole-based Hole-Transport Materials to Realize High-Efficiency Perovskite Solar Cells’ ACS Appl. Mater. Inter. 7405-7415, 60, 2021.
    • J. Han, M. Won, J. H. Kim, E. Jung, J. Paramesh, K. Min, J. S. Kim, ‘Cancer Stem Cell-targeted Bio sensing & Chemotherapeutic Perspective’ Chem. Soc. Rev., 49, 7856-7878, 2020.
    • S. Son, J. H. Kim, X. Wang, C. Zhang, S. A. Yoon, J. Shin, A. Sharma, M. H. Lee, L. Cheng, J. Wu, J. S. Kim, ‘Multifunctional sonosensitizers in sonodynamic cancer therapy’ Chem.Soc.Rev., 3244-3261, 49, 2020.
    • J. Xie, T. Fan, J. H. Kim, Y. Xu, Y. Wang, W. Liang, L. Qiao, Z. Wu, Q. Liu, W. Hu, N. Yin, L. Yang, L. Liu, J. S. Kim, H. Zhang, ‘Emetine Loaded Black Phosphorus Hydrogel Sensitizes Tumor to Photothermal Therapy through Inhibition of Stress Granule Formation’ Adv. Func. Mater., 30, 2003891, 2020.
    • M. Li, Y. Shao, J.H. Kim, Z. Pu, X. Zhao, H. Huang, T. Xiong, Y. Kang, G.-Z. Li, K. Shao, J. Fan, J. W. Foley, J. S. Kim, X. Peng, ‘Unimolecular Photodynamic O2-Econemizer to Overcome Hypoxia Resistance in Phototherapeutic’ J. Am. Chem. Soc., 5380-5388, 142, 2020.
    • B. Rathore, K. Sunwoo, P. Jangili, J. Kim, J. H. Kim, M. Huang, J. Xiong, A. Sharma, Z. Yang, J. Qu, and J. S. Kim ‘Nanomaterial designing strategies related to cell lysosome and their biomedical applications: A review’ Biomaterials, 211, 25-47, 2019.
    • H. Singh, J.-Y. Lim, A. Sharma, D. W. Yoon, J. H. Kim, Z. Yang, J. Qu, J. Kim, S. G. Lee, J. S. Kim, ‘A pH-Responsive Glycyrrhetinic acid-Modified Small Molecular Conjugate for NIR Imaging of Hepatocellular Carcinoma (HCC)’ ChemBioChem 614-620, 20, 2019.

안주성 (Jusung An)

Research interest

Small-molecular Optical Imaging

Asan Sci. 346
jusung0614 at
  • J. An, P. Verwilst, H. Aziz, J. Shin, S. Lim, I. Kim, Y. K. Kim, J. S. Kim, ‘Picomolar-Sensitive β-Amyloid Fibril Fluorophores by Tailoring the Hydrophobicity of Biannulated π-Elongated Dioxaborine-Dyes’ Bioact. Mater., 2022, 13, 239-248. Read here

  • Y. Xu, Y. Wang, J. An, A. C. Sedgwick, M. Li, J. Xie, W. Hu, J. Kang, S. Sen, A. Steinbrueck, B. Zhang, L. Qiao, S. Wageh, J. F. Arambula, L. Liu, H. Zhang, J. L. Sessler, J. S. Kim, ‘2D-Ultrathin MXene/DOXjade Platform for Iron Chelation Chemo-photothermal Therapy’ Bioact. Mater., 2022, 14, 76-85. Read here

  • Z. Mao, J. Xiong, P. Wang, J. An, F. Zhang, Z. Liu, J. S. Kim, ‘Activity-based Fluorescence Probes for Pathophysiological Peroxynitrite Fluxes’ Coord. Chem. Rev., 2022, 454, 214356. Read here

    • N. Singh, S. Son, J. An, I. Kim, M. Choi, N. Kong, W. Tao, J. S. Kim, ‘Nanoscale porous organic polymers for drug delivery and advanced cancer theranostics’ Chem. Soc. Rev., 2021, 50, 12883-12896. Read here

    • J. An, P. Jangili, S. Lim, Y. K. Kim, P. Verwilst, J. S. Kim ‘Multichromatic Fluorescence towards Aberrant Proteinaceous Aggregates utilizing Benzimidazole-based ICT Fluorophores’ J. Incl. Phenom. Macrocycl. Chem., 2021, 101, 205-215. Read here

    • S. Wang, W. X. Ren, J-T. Hou, M. Won, J. An, X. Chen, J. Shu and J. S. Kim ‘Fluorescence imaging of pathophysiological microenvironments’ Chem. Soc. Rev., 2021, 50, 8887-8902. Read here

    • E. Jung, I. Shim, J. An, M. S. Ji, P. Jangili, S-G. Chi, J. S. Kim ‘Phenylthiourea-conjugated BODIPY as an efficient photosensitizer for tyrosinase-positive melanoma-targeted photodynamic therapy’ ACS Appl. Bio Mater., 2021, 4, 2120-2127. Read here

    • Y. Ren, A. C. Sedgwick, J. Chen, G. Thiabaud, C. V. Chau, J. An, J. F. Arambula, X-P. He, J. S. Kim, J. L. Sessler, C. Liu ‘Manganese(II) Texaphyrin: A Paramagnetic Photoacoustic Contrast Agent Activated by Near-IR Light’ J. Am. Chem. Soc., 2020, 142, 16156-16160. Read here

    • J. Li, Y. Zhang, P. Wang, L. Yu, J. An, G. Deng, Y. Sun, J. S. Kim ‘Reactive Oxygen Species, Thiols and Enzymes Activable AIEgens from Single Fluorescence Imaging to Multifunctional Theranostics’ Coord. Chem. Rev., 2020, 427, 213559. Read here

    • Y. Xu, Y. Zhang, J. Li, J. An, C. Li, S. bai, A. Sharma, G. Deng, J. S. Kim, Y. Sun, ‘NIR-II Emissive Multifunctional AIEgen with Single Laser-Activated Synergistic Photodynamic/Photothermal Therapy of Cancers and Pathogens’ Biomaterials, 2020, 259, 120315. Read here

    • Y.-H. Zhang, X. Li, L. Huang, H. S. Kim, J. An, M. Lan, Q.-Y. Cao, J. S. Kim, ‘AIE based GSH activatable photosensitizer for imaging-guided photodynamic therapy’ Chem. Commun., 2020, 56, 10317-10320. Read here

    • Z. Xie, T. Fan, J. An, W. Choi, Y. Duo, Y. Ge, B. Zhang, G. Nie, N. Xie, H. Zhang, J. S. Kim, ‘Emerging combination strategies with phototherapy in cancer nanomedicine’ Chem. Soc. Rev., 2020, 49, 8065-8087. Read here

    • J. Wu, L. Jiang, P. Verwilst, J. An, H. Zeng, L. Zeng, G. Niu, J. S. Kim ‘A colorimetric and fluorescence lighting-up sensor based on ICT coupled with PET for rapid, specific and sensitive detection of nitrite in food’ Chem. Commun., 2019, 55, 9947-9950. Read here

김재원 (Jaewon Kim)

Research interest

Organic synthesis & Photodynamic therapy

Asan Sci. 337
kcjb2929 at
  • J. Kim, S. Lee, M. S. Han, ‘pH-guided fluorescent sensing probe for the discriminative detection of Cl and Br in human serum’ Anal. Chim. Acta, 2022, 1210, 339879.
  • L.-X. Huang, Y.-B. He, J. Kim, A. Sharma, QY Cao, J. S. Kim, ‘Pyridinium-conjugated polynorbornenes for nanomolar ATP sensing using an indicator displacement assay and a PET strategy’ Chem. Commun., 2021, 57, 13530-13533.
  • J. Kim, S. Lee, S. Kim, M. Jung, H. Lee, M. S. Han, ‘Development of a fluorescent chemosensor for chloride ion detection in sweat using Ag+-benzimidazole complexes’ Dyes Pigm., 2020, 108291.

Hao Xiong

Research interest

Design, synthesis and applications of fluorescent sensors

Asan Sci. 238
haopaul at
  • T. Chen, H. Xiong, J. F. Yang, X.-L. Zhu, R.-Y. Qu*, G.-F. Yang*, Diaryl Ether: A Privileged Scaffold for Drug and Agrochemical Discovery. J. Agric. Food Chem. 2020, 68, 9839-9877.
  • S.-Y. Liu, H. Xiong, R.-R. Li, W.-C. Yang*, G.-F. Yang*, Activity-based Near-Infrared Fluorogenic Probe Enables In Vitro and In Vivo Profiling of Neutrophil Elastase. Anal. Chem. 2019, 91, 3877-3884.
  • H. Xiong, R.-R. Li, S.-Y. Liu, F.-X. Wu, W.-C. Yang*, G.-F. Yang*, Discovery of Specific Nonpeptide Probe for Chymotrypsin via Molecular Docking-based Virtual Screening and the Application. ACS Appl. Bio Mater. 2018, 1, 310-317.
    • H. Xiong, J.-Q. Yang, W.-M. Kang, F.-X. Wu, J.-L. Zuo, Z.-Y. Zhou, W.-C. Yang*, G.-F. Yang*, Fluorogenic and Chromogenic Detection of Carboxypeptidase Y with a Nonpeptide-Based Small-Molecule Probe. Sens. Actuators B Chem. 2018, 269, 127-134.
    • S.-Y. Liu, H. Xiong, J.-Q. Yang, S. H. Yang, W.-C. Yang*, G.-F. Yang*, Discovery of Butyrylcholinesterase-Activated Near-infrared Fluorogenic Probe for Live-Cell and In Vivo Imaging. ACS Sens. 2018, 3, 2118-2128. (ACS Editors\' Choice)
    • L. Wu, S. H. Yang, H. Xiong, J. Q. Yang, J. Guo, W. C. Yang*, G.-F. Yang*, Nonpeptide-Based Small-Molecule Probe for Fluorogenic and Chromogenic Detection of Chymotrypsin. Anal. Chem. 2017, 89, 3687-3693.
    • S.-H. Yang, Q. Sun, H. Xiong, S.-Y. Liu, B. Moosavi, W.-C. Yang*, G.-F. Yang*, Discovery of a Butyrylcholinesterase-specific Probe via a Structure-based Design Strategy. Chem. Commun. 2017, 53, 3952-3955.

Qihang Ding

Research interest

Fabrication of organic small molecule probes in the NIR-II

Asan sci. 238
dingqihang at
  • Q. Li, Q. Ding, Y. Li, X. Zeng, Y. Liu, S. Lu, H. Zhou, X. Wang, J.Wu, X. Meng, Z. Denga and Y. Xiao ‘Novel small-molecule fluorophores for in vivo NIR-IIa and NIR-IIb imaging’ Chemical Communications. doi:10.1039/c9cc09865h
  • Y. Li, Y. Liu, Q. Li, X. Zeng, T. Tian, W.Zhou, Y. Cui, X. Wang, X. Cheng, Q. Ding, X. Wang, J. Wu, H. Deng, Y. Li, X. Meng, Z. Deng, X. Honga, and Y. Xiao ‘Novel NIR-II organic fluorophores for bioimaging beyond 1550 nm’ Chemical Science. doi:10.1039/c9sc06567a
  • H. Zhou, W. Yi, A. Li, B. Wang, Q. Ding, L. Xue, X. Zeng, Y. Feng, Q. Li, T. Wang, Y. Li, X. Cheng, L. Tang, Z. Deng, M. Wu, Y. Xiao, and X. Hong ‘Specific Small‐Molecule NIR‐II Fluorescence Imaging of Osteosarcoma and Lung Metastasis’ Advanced Healthcare Materials. doi:10.1002/adhm.201901224
    • J. Lin, Q. Li, X. Zeng, Z. Chen, Q. Ding, Y. Li, H. Zhou, X. Meng, D. Chen, Z. Deng, X. Hong and Y. Xiao ‘A novel small-molecule near-infrared II fluorescence probe for orthotopic osteosarcoma imaging’ SCIENCE CHINA Chemistry 63, 766 (2020); doi: 10.1007/s11426-019-9685-6